|
| First author (year) | No. (M/F) | Age (yrs) | Disease duration | Eligibility criteria | Comparisons | AEs | Comparability at baseline |
|
|
Liu, 2004 [42] | T: ;
C: | T: 68.5;
C: 64.5 | 1 m~20 yrs
(for all) | Unclear | Self-prescribed herbal patch versus sodium hyaluronate for the treatment of 5 weeks | No AEs were identified | Unclear |
|
| Cheng, 2009 [44] | 238/122 (for all) | 54.8 (for all) | 2 m~20 yrs (for all) | The standard of TCM syndrome diagnostic and efficacy | San Huang patch versus Gu Tong patch for the treatment of 12 days | Unclear | Yes |
|
| Dong, 2007 [46] | T: ;
C: | T: 65.3;
C: 68.2 | T: 3.2; C: 3.4 | ACR | Shu Jin patch versus Zhi Tong Xiao Yan patch for the treatment of 12 days | No AEs were identified | Yes |
|
| Feng*, 2006 [43] | T: ;
C: | Not reported | T: ;
C: | Hemigou | Gu Ci patch versus one control patch for the treatment of 9 days | No AEs were identified | Unclear |
|
| Kuang, 2010 [12] | T: ;
C: | T: ;
C: | T: ;
C: | ACR and clinical research guidelines of traditional Chinese patent drug | Zhong Tong Xiao Babu patch versus Zhong Tong Xiao patch for the treatment of 10 days | Unclear | Yes |
|
| Liu, 2008 [49] | 122/238 (T: 260; C: 100; for all) | 54.8
(for all) | 2 m~50 yrs
(for all) | ACR | Hei Hu patch versus Qian Shan Huo Xue patch for the treatment of 5 weeks | T: redness, oozing, purulent or itching, rash mentioned; C: fewer people of itching | Yes |
|
| Wang, 2005 [45] | T: 48; C: 16
(for all) | 16~72 yrs
(for all) | 1~20 yrs
(for all) | ACR | Zhen Tong Xiao Yan patch versus Fu Fang Nan Xing Zhi Tong patch for the treatment of 28 days | Unclear | Unclear |
|
| Wen, 2008 [34] | T: ;
C: | T: 48~75 yrs;
C: 47~72 yrs | T: 3 m~5 yrs;
C: 47~74 yrs | ACR and clinical research guidelines of traditional Chinese patent drug | Xi Tong Kang patch versus Tong Luo Qu Tong pacth for the treatment of 28 days | Unclear | Yes |
|
| Xu, 2000 [48] | T: ; C: 20 (25) | T: 62.3;
C: not reported | 6 cases less than 1 year; 32 cases between 1 and 3 yrs; 28 cases more than 3 yrs | ACR | Fu Fang San sheng patch versus Zhuang Gu Guan Jie pill | 2 cases showed local skin itching within 48 h after patching, which disappeared after a day by the discontinuation, but not affecting patching | Unclear |
|
| Zhang, 2010 [50] | T: ;
C: | T: 48.6;
C: 51 | : 1 m~3 yrs;
: 1.5 m~3 yrs | ACR and clinical research guidelines of traditional Chinese patent drug | Gu Ci patch versus She Xiang Zhuang Gu patch for the treatment of 10 days | No AEs were identified | Unclear |
|
| Zhang, 2010 [33] | T: ;
C: | T 45~85;
C 45~80 | T: 3 m~5 yrs;
C: 3 m~5 yrs | COA and the standard of TCM syndrome diagnostic and efficacy | Wen Tong patch versus Tong Luo Qu Tong patch for the treatment of 28 days | Unclear | Yes |
|
| Zhao, 2007 [47] |
(for all)
| 10 cases (15 m~30 yrs); 20 cases (31~45 yrs);
35 cases (45 m~60 yrs); 47 cases more than 61 yrs | 30 cases (6 m~3 yrs); 37 cases more than 10 yrs | The standard of TCM syndrome diagnostic and efficacy | Gu Bi Tong patch versus Fu Fang Nan Xing zhi Tong patch with 1-year follow-ups | Unclear | Unclear |
|
