Ethanolic Extract of Butea monosperma Leaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation

Table 1

Effect of ethanolic extract of BM on insulin secretion from isolated rat islets.

Group	Insulin secretion (ng/mg islet protein)
	Glucose: 3 mM	Glucose: 11 mM
Control	2.99 (2.65–4.27)	5.41 (4.91–9.27)*
BM 20 μg/mL	2.65 (2.23–3.71)	5.19 (4.41–8.72)
BM 40 μg/mL	3.45 (2.67–3.99)	5.31 (4.18–7.67)
BM 80 μg/mL	5.28 (3.87–6.09)*	7.84 (6.98–9.54)*
Glibenclamide (10 μg/L)	5.89 (4.34–6.95)*	8.92 (7.67–9.86)*

Isolated rat islets were incubated for 60 min with ethanol extract BM (10, 20, and 30 mg/mL) in the presence of 3 or 11 mM glucose. Data are presented as median (range), n = 5. Mann-Whitney U-test was used to evaluate statistical significance. *P < 0.05 compared with control (3 mM glucose without extract).