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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 362573, 11 pages
http://dx.doi.org/10.1155/2014/362573
Research Article

Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity

1Herbal Medicine Formulation Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea
2Division of Non-Clinical Studies, Korea Institute of Toxicology, Daejeon 305-343, Republic of Korea

Received 15 May 2014; Revised 22 August 2014; Accepted 25 August 2014; Published 5 November 2014

Academic Editor: Dae Gill Kang

Copyright © 2014 Soo-Jin Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. D. Park, Prescriptionology, Young Lim Press, Seoul, Republic of Korea, 2003.
  2. M. Li, W. Wang, P. Wang, K. Yang, H. Sun, and X. Wang, “The pharmacological effects of morroniside and loganin isolated from liuweidihuang wan, on MC3T3-E1 cells,” Molecules, vol. 15, no. 10, pp. 7403–7414, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. K.-S. Shim, C. J. Ma, D.-S. Kim, and J. Y. Ma, “Yukmijihwang-tang inhibits receptor activator for nuclear factor-κB ligand-induced osteoclast differentiation,” Journal of Medicinal Food, vol. 14, no. 11, pp. 1439–1447, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. C.-R. Wu, L.-W. Lin, W.-H. Wang, and M.-T. Hsieh, “The ameliorating effects of LiuWei Dihuang Wang on cycloheximide-induced impairment of passive avoidance performance in rats,” Journal of Ethnopharmacology, vol. 113, no. 1, pp. 79–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Kang, J.-H. Kim, C. Cho et al., “Effects of Yukmijihwang-tang derivatives (YMJd) on ibotenic acid-induced amnesia in the rat,” Biological and Pharmaceutical Bulletin, vol. 29, no. 7, pp. 1431–1435, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. J.-J. Shen, C.-J. Lin, J.-L. Huang, K.-H. Hsieh, and M.-L. Kuo, “The effect of liu-wei-di-huang wan on cytokine gene expression from human peripheral blood lymphocytes,” The American Journal of Chinese Medicine, vol. 31, no. 2, pp. 247–257, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Rho, M. Kang, B. Choi et al., “Effects of Yukmijihwang-tang derivatives (YMJd), a memory enhancing herbal extract, on the gene-expression profile in the rat hippocampus,” Biological and Pharmaceutical Bulletin, vol. 28, no. 1, pp. 87–93, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. I. S. Shin, M. Y. Lee, H. K. Ha, C. S. Seo, and H.-K. Shin, “Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplasia in rats,” BMC Complementary and Alternative Medicine, vol. 12, article 48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. OECD, “Principles on Good Laboratory Practice,” 1997.
  10. Y.-M. Xue, R. Luo, B. Zhu, Y. Zhang, Y.-H. Pan, and C.-Z. Li, “Effects of liuwei dihuang pills on expressions of apoptosis-related genes bcl-2 and Bax in pancreas of OLETF rats,” Zhong Xi Yi Jie He Xue Bao, vol. 3, no. 6, pp. 455–458, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. D. G. Kang, E. J. Sohn, M. K. Moon et al., “Yukmijihwang-tang ameliorates ischemia/reperfusion-induced renal injury in rats,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 47–53, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Wang, K. Yao, X. Yang et al., “Chinese patent medicine liu wei di huang wan combined with antihypertensive drugs, a new integrative medicine therapy, for the treatment of essential hypertension: a systematic review of randomized controlled trials,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 714805, 7 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Ha, J. K. Lee, and H. Y. Lee, “Safety evaluation of Yukmijihwang-tang: assessment of acute and subchronic toxicity in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 672136, 8 pages, 2011. View at Publisher · View at Google Scholar
  14. H. Ha, J. K. Lee, H. Y. Lee et al., “Evaluation of genotoxicity of Yukmijihwang-tang, a herbal formula,” Regulatory Toxicology and Pharmacology, vol. 59, no. 3, pp. 391–396, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Michael, B. Yano, R. S. Sellers et al., “Evaluation of organ weights for rodent and non-rodent toxicity studies: a review of regulatory guidelines and a survey of current practices,” Toxicologic Pathology, vol. 35, no. 5, pp. 742–750, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. R. S. Sellers, D. Morton, B. Michael et al., “Society of toxicologic pathology position paper: organ weight recommendations for toxicology studies,” Toxicologic pathology, vol. 35, no. 5, pp. 751–755, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. C. R. Laboratories, “Clinical laboratory parameters for Crl:CD(SD) rats,” 2006.
  18. World Health Organization, “General laboratory findings in clinical toxicology,” in Basic Analytical Toxicology, WHO, Geneva, Switzerland, 2014. View at Google Scholar
  19. M. T. Cunningham, J. T. Brandt, M. Laposata, and J. D. Olson, “Laboratory diagnosis of dysfibrinogenemia,” Archives of Pathology & Laboratory Medicine, vol. 126, no. 4, pp. 499–505, 2002. View at Google Scholar · View at Scopus
  20. Z. Y. Khoo, C. C. Teh, N. K. Rao, and J. H. Chin, “Evaluation of the toxic effect of star fruit on serum biochemical parameters in rats,” Pharmacognosy Magazine, vol. 6, no. 22, pp. 120–124, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. J. F. Zilva, P. R. Pannal, and P. D. Mayne, Clinical Chemistry in Diagnosis and Treatment, England Clays, St Ives Plc, England, UK, 5th edition, 1991.
  22. C. Johnson-Delaney, Exotic Animal Companion Medicine Handbook for Veterinarians, Zoological Education Network, 1996.
  23. H. Ha, J. K. Lee, H. Y. Lee et al., “Evaluation of safety of the herbal formula Ojeok-san: acute and sub-chronic toxicity studies in rats,” Journal of Ethnopharmacology, vol. 131, no. 2, pp. 410–416, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Ha, J. K. Lee, H. Y. Lee et al., “Genotoxicity assessment of a herbal formula, Ojeok-san,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 586–589, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Barrow, “Reproduction and development of toxicology safety studies,” in The Handbook of Experimental Animals: The Laboratory Rats, G. J. Krinke, Ed., pp. 11–27, Academic Press, London, UK, 2000. View at Google Scholar
  26. A. S. J. P. A. M. van Miert, “The use in animals of drugs licensed for human use only,” in Comparative Veterinary Pharmacology, Toxicology and Therapy, A. S. J. P. A. M. van Miert, M. G. Bogaert, and M. Debackere, Eds., pp. 489–500, MTP Press, Boston, Mass, USA, 1986. View at Publisher · View at Google Scholar