Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity
Table 8
Serum biochemical values of animals treated with YMJ for 4 weeks.
Dose (mg/kg/day)
0
500
1000
2000
Male rats
Glucose (mg/dL)
115.9 ± 13.28
102.8 ± 9.00
102.3 ± 18.22
117.3 ± 17.18
BUN (mg/dL)
10.9 ± 0.84
12.2 ± 0.66
11.7 ± 1.90
12.4 ± 1.35
Creatinine (mg/dL)
0.49 ± 0.057
0.48 ± 0.015
0.52 ± 0.055
0.51 ± 0.040
Total protein (g/dL)
6.25 ± 0.173
6.18 ± 0.308
6.41 ± 0.304
6.33 ± 0.045
Albumin (g/dL)
4.30 ± 0.084
4.28 ± 0.169
4.38 ± 0.105
4.36 ± 0.067
Albumin/globulin ratio
2.21 ± 0.094
2.26 ± 0.121
2.18 ± 0.204
2.23 ± 0.145
Total cholesterol (mg/dL)
61.4 ± 8.99
57.8 ± 9.28
60.6 ± 12.30
60.8 ± 10.85
Triglycerides (mg/dL)
44.7 ± 16.71
49.1 ± 18.69
44.5 ± 14.46
49.4 ± 22.12
Phospholipid (mg/dL)
98 ± 10.7
92 ± 9.9
95 ± 13.9
95 ± 19.4
AST (IU/L)
108.1 ± 8.07
116.7 ± 14.85
121.2 ± 20.65
114.2 ± 14.18
ALT (IU/L)
28.8 ± 4.09
31.5 ± 4.90
35.9 ± 12.72
27.2 ± 1.25
Total bilirubin (mg/dL)
0.096 ± 0.0113
0.105 ± 0.0092
0.112 ± 0.0116
0.098 ± 0.0067
ALP (IU/L)
449.6 ± 34.20
491.2 ± 84.72
476.0 ± 28.92
479.6 ± 94.04
Creatine kinase (IU/L)
527 ± 124.0
639 ± 111.1
656 ± 168.0
637 ± 217.8
Ca (mg/dL)
10.89 ± 0.203
10.55 ± 0.376
10.78 ± 0.425
10.77 ± 0.479
IP (mg/dL)
10.43 ± 0.907
9.86 ± 1.044
10.04 ± 1.174
9.72 ± 0.924
Na (mmol/L)
144 ± 0.9
145 ± 0.7
146 ± 1.5*
146 ± 0.7
K (mmol/L)
7.52 ± 0.800
6.51 ± 1.190
5.80 ± 1.195
6.49 ± 1.255
Cl (mmol/L)
103 ± 1.9
103 ± 1.1
103 ± 1.3
104 ± 2.1
GGT (IU/L)
1.03 ± 1.460
0.15 ± 0.143
0.15 ± 0.143
0.44 ± 0.615
Female rats
Glucose (mg/dL)
110.6 ± 17.45
105.5 ± 15.58
118.9 ± 12.20
91.1 ± 7.68
BUN (mg/dL)
15.76 ± 2.25
13.6 ± 0.82
14.0 ± 2.02
14.4 ± 1.43
Creatinine (mg/dL)
0.60 ± 0.011
0.55 ± 0.007*
0.54 ± 0.011**
0.59 ± 0.029
Total protein (g/dL)
6.76 ± 0.451
6.65 ± 0.255
6.82 ± 0.224
6.76 ± 0.381
Albumin (g/dL)
4.58 ± 0.243
4.65 ± 0.136
4.65 ± 0.118
4.61 ± 0.205
Albumin/globulin ratio
2.10 ± 0.114
2.34 ± 0.120
2.15 ± 0.103
2.16 ± 0.168
Total cholesterol (mg/dL)
70.0 ± 9.72
70.0 ± 12.98
72.6 ± 13.87
75.8 ± 21.81
Triglycerides (mg/dL)
36.5 ± 6.90
34.3 ± 3.47
30.2 ± 7.55
31.6 ± 7.08
Phospholipid (mg/dL)
123 ± 20.2
124 ± 15.1
127 ± 21.5
129 ± 24.9
AST (IU/L)
109.3 ± 17.78
108.7 ± 20.14
101.1 ± 10.93
116.5 ± 24.99
ALT (IU/L)
27.1 ± 4.47
25.9 ± 2.50
24.4 ± 4.06
27.0 ± 3.28
Total bilirubin (mg/dL)
0.112 ± 0.0101
0.116 ± 0.0111
0.118 ± 0.0251
0.117 ± 0.0178
ALP (IU/L)
217.9 ± 20.72
244.9 ± 15.87
261.3 ± 61.05
290.1 ± 99.47
Creatine kinase (IU/L)
498 ± 172.4
518 ± 166.8
387 ± 93.7
520 ± 233.7
Ca (mg/dL)
10.82 ± 0.444
10.80 ± 0.344
11.14 ± 0.316
10.97 ± 0.418
IP (mg/dL)
8.30 ± 0.427
7.84 ± 0.926
8.49 ± 0.770
8.80 ± 0.329
Na (mmol/L)
143 ± 1.6
144 ± 1.3
145 ± 1.1
143 ± 0.8
K (mmol/L)
6.06 ± 0.394
6.23 ± 1.241
6.52 ± 0.350
6.86 ± 0.573
Cl (mmol/L)
104 ± 2.4
105 ± 1.3
104 ± 1.3
103 ± 1.1
GGT (IU/L)
0.92 ± 0.579
0.67 ± 0.524
0.99 ± 0.603
0.99 ± 0.374
ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alkaline phosphatase; BUN, blood urea nitrogen. Values are presented as mean ± SD. * < 0.05 and ** < 0.01 compared with the vehicle control group.
