Review Article

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

Table 1

Chemical constituents of Jatropha gossypiifolia L. described in the literature.

Plant partClassificationCompoundExtract type and/or preparationReference

Whole plantCoumarin-lignoidsPropacinIsolated from dichloromethane : methanol (1 : 1, v/v) extract after successive column chromatography on silica gel[38]
VenkatasinNot specified*[39]
DiterpenesCitlalitrioneIsolated from dichloromethane : methanol (1 : 1, v/v) extract after successive column chromatography on silica gel[40]
JatrophenoneIsolated from dichloromethane : methanol (1 : 1, v/v) extract after successive column chromatography on silica gel[41]

Stem, roots, and seedsCoumarin-lignoidsArylnaphthalene lignanIsolated from petrol ether extract after successive column chromatography on silica gel[42]
GadainIsolated from petrol ether extract after successive column chromatography on silica gel[43]
JatrophanIsolated from petrol ether extract[44]

Aerial partsFlavonoidsDetected by phytochemical screening reactions of ethanol extract[19, 45]
LignansGossypifanIsolated from petrol ether extract after successive column chromatography on silica gel[46]
GossypilineIsolated from dichloromethane : methanol (1 : 1, v/v) extract after successive column chromatography on silica gel[47]
PhenolsQuantitative analysis showed that the petrol ether, chloroform, ethyl acetate, and n-butanol extracts presented, respectively, , , , and  mg of gallic acid equivalents/g of crude extract[48]
SteroidsDetected by phytochemical screening reactions of ethanol extract[19, 45]
TanninsDetected by phytochemical screening reactions of ethanol extract[23, 45]
TriterpenoidsDetected by phytochemical screening reactions of ethanol extract[45]

LeavesAlkaloidsRicinineCompound isolated from ethyl acetate extract from senescent leaves[49]
Detected by phytochemical screening reactions of chloroform and methanol extracts[50]
Quantitative analysis showed 2.81% on leaves[51]
Not specified[30]
Cardiac glycosidesIdentified on leaves by qualitative phytochemical screening reactions[52]
FlavonoidsApigeninIdentified in ether fraction from ethanol extract[53]
IsovitexinIdentified in ethyl acetate and methyl ethyl ketone fractions from ethanol extract[53]
Orientin/isoorientinIsomers identified in different types of extracts from leaves[54]
Schaftoside/isoschaftosideIsomers identified in different types of extracts from leaves[54]
VitexinIdentified in ethyl acetate fraction from ethanol extract[53]
Vitexin/isovitexinIsomers identified in different types of extracts from leaves[54]
Identified on leaves by qualitative phytochemical screening reactions[52]
Quantitative analysis showed 7.4% on leaves[55]
Quantitative analysis showed 2.41% on leaves[51]
PhenolsQuantitative analysis showed 8.6% on leaves[55]
Quantitative analysis showed 0.26% on leaves[51]
PhlobotanninsDetected by phytochemical screening reactions of chloroform and methanol extracts[50]
ProteinsIdentified on leaves by qualitative phytochemical screening reactions[52]
Leaves obtained by micropropagation were macerated in liquid nitrogen and extracted at 4°C for 6 h with 0.1 M NaCl. The material was centrifuged and the limpid supernatant was dialyzed against water at low temperature in a cellulose membrane to remove nonprotein compound with molecular mass below 3.5 kDa[56]
Reducing sugarsIdentified on leaves by qualitative phytochemical screening reactions[52]
SaponinsIdentified on leaves by qualitative phytochemical screening reactions[52]
Quantitative analysis showed 4.15% on leaves[51]
SteroidsIdentified on leaves by qualitative phytochemical screening reactions[52]
TanninsDetected by phytochemical screening reactions of methanol extract[50]
Detected on leaves by qualitative phytochemical screening reactions[52]
Quantitative analysis showed 5.14% on leaves[51]
TerpenoidsDetected on leaves by qualitative phytochemical screening reactions[52]
Triterpenes(2 , 13 , 14 , 20S)-2,24,25-Trihydroxylanost-7-en-3-oneIsolated from the ethanol extract after successive partitions procedures and column chromatography on silica gel and preparative TLC[57]
(13 , 14 , 20S)-2,24,25-Trihydroxylanosta-1,7-dien-3-oneIsolated from the ethanol extract after successive partition procedures and column chromatography on silica gel and preparative TLC[57]

StemsAlkaloidsQuantitative analysis showed 2.16% of alkaloid on stems[51]
Coumarin-lignoids4′-O-Demethyl retrochinensinNot specified[58]
Cleomiscosin ACompound isolated from ethyl acetate fraction stems after successive column chromatography on silica gel[59]
GossypidienCompound isolated from hexane extract from dried stems after successive column chromatography on silica gel[60]
IsogadainNot specified*[61]
JatrodienCompound isolated from petrol ether extract after successive column chromatography on silica gel[62]
PrasanthalineNot specified*[63]
FlavonoidsQuantitative analysis showed 1.2% on stems[51]
PhenolsQuantitative analysis showed 0.13% on stems[51]
SaponinsQuantitative analysis showed 2.18% on stems[51]
TanninsQuantitative analysis showed 1.36% on stems[51]

RootsAlkaloidsQuantitative analysis showed 1.6% on roots[51]
Diterpenes2 -HydroxyjatrophoneIsolated from petrol ether extract after successive column chromatography on silica gel[64]
2 -Hydroxy-5,6-isojatrophoneIsolated from petrol ether extract after successive column chromatography on silica gel[64]
2 -HydroxyjatrophoneIsolated from petrol ether extract after successive column chromatography on silica gel[64]
CitlalitrioneIsolated from petrol ether fraction from the methanol extract after successive column chromatography on silica gel[13]
FalodoneIsolated from petrol ether fraction from the methanol extract after successive column chromatography on silica gel[13]
Jatropholone ANot specified*[65]
Jatropholone BNot specified*[65]
JatrophoneIsolated from ethanol extract[66]
FlavonoidsQuantitative analysis showed 1.75% on roots[51]
PhenolsQuantitative analysis showed 0.24% on roots[51]
SaponinsQuantitative analysis showed 2.83% on roots[51]
TanninsQuantitative analysis showed 2.73% on roots[51]

SeedsAlkaloidsQuantitative analysis showed 2.36% on seeds[51]
Amino acidsNot specified*[67]
CarbohydratesQuantitative analysis showed 30.32% on seeds[68]
Not specified*[67]
Esters12-Deoxy-16-hydroxylphorbolIsolated from hydrophilic fraction from the ether extract, by countercurrent chromatography[69]
Fatty acidsArachidic acidIdentified in petrol ether extract[68, 70]
Caprilic acidIdentified in petrol ether extract[68, 70]
Lauric acidIdentified in petrol ether extract[68, 70]
Lignoceric acidIdentified in petrol ether extract[68, 70]
Linoleic acidIdentified in petrol ether extract[68, 70]
Myristic acidIdentified in petrol ether extract[68, 70]
Oleic acidIdentified in petrol ether extract[68, 70]
Palmitic acidIdentified in petrol ether extract[68, 70]
Palmitoleic acidIdentified in petrol ether extract[68, 70]
Ricinoleic acidIdentified in petrol ether extract[68, 70]
Stearic acidIdentified in petrol ether extract[68, 70]
Vernolic acidIdentified in petrol ether extract[68, 70]
FibersQuantitative analysis showed 9.25% on seeds[68]
FlavonoidsQuantitative analysis showed 2.26% on seeds[51]
PhenolsQuantitative analysis showed 0.18% on seeds[51]
ProteinsQuantitative analysis showed 13.40% on seeds[68]
SaponinsQuantitative analysis showed 2.37 on seeds[51]
Quantitative analysis showed 6 g/kg on seeds[68]
TanninsQuantitative analysis showed 3.52% on seeds[51]

LatexProteinsCyclogossine ANot specified[71]
Cyclogossine BIsolated from ethyl acetate extract by gel filtration column chromatography [20]

Not specifiedAlkaloidsImidazole alkaloidIsolated from the plant exudates*[72]
PiperidineIsolated from the plant exudates*[72]
DiterpenoidsAbiodoneNot specified*[73]

The complete version of the paper was not accessible, so the information was obtained from its abstract.