Protection of Tong-Sai-Mai Decoction against Apoptosis Induced by H₂O₂ in PC12 Cells: Mechanisms via Bcl-2-Mitochondria-ROS-INOS Pathway

Figure 10

Revealing that TSM reduced H₂O₂-induced increase in intracellular ROS concentration in PC12 cells. The level of ROS was assessed by MFI of Dihydrorhodamine 123 (DHR) in ten thousand of PC12 cells. The control group did not change the ROS level but when cotreated with various concentrations of TSM would attenuate an increase in ROS level induced by H₂O₂ at 200 μmol/L (TSM + H₂O₂). and as compared with the control group; and as compared with the H₂O₂ group.

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