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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 373608, 5 pages
Research Article

Observations of TCRV Gene Expression in Rats with Dampness Syndrome

Department of Traditional Chinese Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China

Received 26 January 2014; Accepted 6 May 2014; Published 15 May 2014

Academic Editor: Qing He

Copyright © 2014 Yan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Environmental dampness is one factor which can cause human diseases. The effects of exposure to humidity on human immune function are diverse and numerous. In the theory of traditional Chinese medicine (TCM), dampness is defined as one of the major pathogenic factors in the human body. It is divided into “external dampness” and “internal dampness.” However the molecular mechanism leading to humidity-induced immunosuppression is obscure. In the present study, we investigated the expression of the T-cell antigen receptor variable (TCRV) subfamilies in rats which were fed in different humid environment. And the expression levels of the TCRV subfamilies were detected using FQ-PCR. We found that the dampness might reduce the immunological recognition function of rats. And the obstruction of the immunological recognition function might be caused by internal dampness rather than external dampness.