Effects of Brown Seaweed (Sargassum polycystum) Extracts on Kidney, Liver, and Pancreas of Type 2 Diabetic Rat Model
Figure 3
Photomicrographs of Renal tissues of rats from different experimental groups. (a) Renal Cortex of normal control rats show renal corpuscle and tubules with moderate congestion of the cortical blood vessels (200x). (b) Diabetic rats Renal Cortex shows severe cellular injury, hydropic degeneration and swelling (black arrow), glomerular atrophy and widening of the bowman’s space (dashed black arrow), and necrotic tubular epithelium (pyknotic nuclei and acidophilic cytoplasm—white arrow) (200x). (c) Renal Cortex of metformin treated diabetic rats shows moderate cellular hydropic degeneration (dashed black arrow), atrophied renal corpuscle (black arrow), and mild glomerular capillaries congestion (white arrow) (200x). (d) Renal Cortex of 300 mg ethanol extract treated diabetic rats shows severe glomerular atrophy and accumulation of protein acious inflammatory pinkish fluid in the glomerular spaces (black arrow), severe necrosis of the tubular epithelium with degenerative cells (dashed black arrows), congestion, and a few inflammatory cells (white arrow) (200x). (e) Renal Cortex of 300 mg water extract treated diabetic rats shows mild cellular degeneration and swelling (star shaped tubular lumen—dashed black arrow), mild fatty changes in the glomerular epithelial capillaries (black arrows), and mild changes in the glomerulus (white arrow) (200x). (f) Renal Cortex of 150 mg ethanol extract treated diabetic rats shows swelling in the tubular epithelium (black arrow), mild congestion, and degeneration of the glomerular capillary cells (dashed black arrow) (200x). (g) Renal Cortex of 150 mg water extract treated diabetic rats shows mild to moderate cellular degeneration (dashed black arrow), mild glomerular atrophy (black arrow), and hyaline cast pinkish amorphous protein within the tubular lumen (white arrow) (200x).
