Effects of Brown Seaweed (Sargassum polycystum) Extracts on Kidney, Liver, and Pancreas of Type 2 Diabetic Rat Model

Table 2

Percentage of total damaged cells in the experimental animals at the end of study.

Treatments	Endocrine pancreas (islets of Langerhans)		Liver		Kidney
	Percentage of total damage	Difference (%)	Percentage of total damage	Difference (%)	Percentage of total damage	Difference (%)
NC	4.60 ± 0.82^D	—	5.3 ± 0.2^F	—	3.8 ± 0.1^G	—
DC	51.14 ± 1.57^A	91.00%	62.8 ± 0.6^B	91.56%	64.5 ± 0.3^B	94.0%
DE300	29.46 ± 1.47^C	84.38%	65.1 ± 0.6^A	91.86%	69.4 ± 0.3^A	94.5%
DE150	34.45 ± 2.17^B	86.65%	5.4 ± 0.2^F	1.85%	13.2 ± 0.4^F	71.2%
DW300	31.55 ± 1.25^BC	85.42%	32.9 ± 0.4^C	83.9%	45.8 ± 0.4^C	91.7%
DW150	35.17 ± 0.83^B	86.92%	19.8 ± 0.5^D	73.23%	17.4 ± 0.1^D	78.2%
DM	30.18 ± 1.18^C	87.76%	7.8 ± 0.4^E	32.00%	15.2 ± 0.4^E	75.0%

A,B,C,D,FValues with the same superscript/s within column do not differ significantly at 𝑃<0.05. Values are expressed as Mean ± SE (𝑛=6). Difference percentage was calculated for treated groups compared to NC group. NC: normal control group. DC: diabetic control group. DE300: diabetic group treated with 300 mg/kg/BW of the ethanolic extract. DE150: diabetic group treated with 150 mg/kg/BW of the ethanolic extract. DW300: diabetic group treated with 300 mg/kg/BW of the water extract. DW150: diabetic group treated with 150 mg/kg/BW of the water extract. DM: diabetic group treated with 250 mg/kg/BW of metformin.