Salidroside Reduces Cell Mobility via NF-κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells

Figure 2

Salidroside exhibits antimigratory property in BV2 microglial cells. ((a), (b)) The wound scratch assay was carried out to analyze motility of LPS-activated BV2 cells. Representative phase contrast images show the width of scratch captured at 12 h after scraping. The cell migration distances were determined with the ratios of wound closure. ((c), (d)) Determination of BV2 cell migration by transwell migration assay. Cells were fixed, stained, and examined microscopically in five random fields at 100x magnification after 24 h treatment and then were harvested and read with microplate reader. Absorbance correlating with the number of cells invaded expressed as mean ± SD (𝑛=3). ^#𝑃<0.05 versus the control group; ^∗𝑃<0.05 versus LPS group.

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