A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

Table 5

Plasma differential metabolites for discriminating phlegm from blood-stasis syndrome.

Mode	RT	Mass	Metabolite	VIP	𝑃	^aFold
EIS^+	1.21	131.10	L-Leucine	1.83	9.54𝐸−04	−0.62
	1.02	168.03	Uric acid	1.73	1.91𝐸−03	−1.32
	2.00	165.08	L-Phenylalanine	1.68	2.81𝐸−03	−0.37
	3.82	204.09	L-Tryptophan	1.62	4.05𝐸−03	−0.26
	10.94	250.12	Ubiquinone	1.57	5.38𝐸−03	−0.81
	15.21	384.29	17,20-dimethyl prostaglandin F1α	1.57	5.61𝐸−03	0.75
	3.82	145.05	Isoquinoline N-oxide	1.55	6.08𝐸−03	−0.26
	10.96	393.29	PGH2-EA	1.54	6.46𝐸−03	0.43
	17.48	283.29	Stearamide	1.54	6.56𝐸−03	−1.71
	11.74	568.33	Deoxycholic acid 3-glucuronide	1.52	7.62𝐸−03	0.88
	16.85	368.29	Octadecyl fumarate	1.50	8.10𝐸−03	1.10
EIS^−	10.28	250.12	Ubiquinone	2.70	5.97𝐸−10	−1.15
	17.23	363.24	N-Palmitoyl taurine	2.58	1.05𝐸−08	−2.33
	17.46	389.26	N-Oleoyl taurine	2.57	1.11𝐸−08	−1.95
	16.68	552.19	Deoxycholic acid disulfate	2.26	2.43𝐸−06	−2.08
	1.08	181.07	L-Tyrosine	1.76	5.73𝐸−04	0.56
	1.03	244.07	Uridine	1.70	9.09𝐸−04	−0.28
	0.74	130.03	Itaconic acid	1.68	1.06𝐸−03	1.44
	1.04	308.04	Deoxyuridine monophosphate (dUMP)	1.63	1.64𝐸−03	−1.04
	16.75	330.26	Eicosapentaenoic acid ethyl ester	1.63	1.65𝐸−03	4.77

aFold = log₂(average peak intensity of phlegm syndrome/average peak intensity of blood stasis syndrome); “−” represented downregulated compared to blood stasis syndrome; “+” represented upregulated compared to blood stasis syndrome.