Pharmacokinetic and Pharmacodynamic Comparison of Chinese Herbal Ointment Liu-He-Dan and Micron Liu-He-Dan Ointment in Rats with Acute Pancreatitis

Table 1

Pharmacokinetic parameters of LHD and MLHD components in AP model rats (𝑛=5).

Parameters	Emodin		Aloe emodin		Physcion
	MLHD	LHD	MLHD	LHD	MLHD	LHD
𝑇1/2𝛼 (h)	1.14 ± 1*	5.8 ± 1.6	2.1 ± 0.4*	1.1 ± 0.6	1.7 ± 0.8*	3.9 ± 0.6
AUC (0–𝑡) (ng/L∗h)	23.2 ± 8*	39.6 ± 9.2	44.6 ± 16.1*	21.2 ± 4.5	319 ± 76	437 ± 129
MRT (0–𝑡) (h)	14.1 ± 1.4	16 ± 1.5	13.7 ± 0.6	13.6 ± 1.1	13.2 ± 1.1	14.5 ± 1.1
𝑇max (h)	1.2 ± 0.45	0.8 ± 0.3	2.2 ± 1.1	1.5 ± 0.7	2.8 ± 1.1*	5.6 ± 2.2
𝐶max (ng/L)	2.79 ± 1.39	2.24 ± 0.71	3.2 ± 0.9	2.08 ± 0.78	19.2 ± 9.5	24.2 ± 9.8

AUC: area under the curve; MRT: mean retention time; *compared to LHD group, 𝑃<0.05.