Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats

Figure 4

Visual predictive check of the pharmacokinetic model for baclofen. The observed plasma concentration and urinary excretion data after oral administration of baclofen (1 mg/kg) to rats pretreated with (a) distilled water (control), (b) Oyaksungisan (OY), or Achyranthes bidentata radix (AB) extract (closed circles) are shown with lines representing the median population predictions and 10th, 25th, 75th, and 90th percentiles according to the pharmacokinetic model described in Figure 3.

(a)

(b)

(c)