Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats

Table 1

Average noncompartmental pharmacokinetic parameters of baclofen obtained after oral administration of baclofen (1 mg/kg) to each pretreated group. Distilled water (control) or each herbal medicine, that is, Oyaksungisan (OY) or Achyranthes bidentata radix (AB) extract, was administered orally for 7 consecutive days. On the final day, baclofen was administered orally after 10 min of the distilled water or each herbal medicine.

Parameters	Control ()	OY ()	AB extract ()
(hr)	4.10 ± 2.52	3.42 ± 0.74	3.64 ± 1.33
(hr)	0.67 ± 0.26	1.25 ± 0.50^*	0.45 ± 0.11
(ng/mL)	744.00 ± 252.96	441.50 ± 63.30^*	831.80 ± 53.00
AUCall (ng·hr/mL)	2042.33 ± 247.68	1899.00 ± 167.91	2144.54 ± 231.19
AUCinf (ng·hr/mL)	2051.75 ± 259.74	1905.79 ± 168.62	2152.10 ± 233.63
(L/kg)	2.78 ± 1.32	2.60 ± 0.54	2.41 ± 0.83
CL/ (mL/min/kg)	8.23 ± 1.06	8.80 ± 0.78	7.82 ± 0.85
(%)	62.40 ± 8.56	61.08 ± 5.02	61.31 ± 14.25
(%)	88.02 ± 11.14	81.76 ± 7.23	92.33 ± 10.02

versus control.