Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain

Figure 4

Effect of p.o. administration of the dried peels of C. kawachiensis on LPS-induced microglial activation. (a) Sagittal sections of the hippocampus were stained with anti-IBA1 antibody. Scale bar shows 50 μm. Results of quantitative analysis of number (b) and the area (c) of IBA1-positive cells by use of ImageJ software are shown. Values are means ± SEM (𝑛 = 8~10 for each group). Symbols indicate significant differences versus nontreated group (^∗∗∗𝑃<0.001) and versus LPS-treated group (^#𝑃<0.05, ^##𝑃<0.01, and ^###𝑃<0.001).

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