Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 3

Review Article

The Effect of Complementary and Alternative Medicine on Subfertile Women with In Vitro Fertilization

Table 3

Summary of the effect of the clinical studies of artificial cycle sequential therapies with CHM on IVF outcomes.

Study IDDesignSample sizeInterventionsOutcomes Composition Limitation

121Single-blind RCT60Treatment arm: CHM + COH
Control arm: COH
Treatment arm: PR, 46.7% [14 of 30]
Control arm: PR, 35.3% [10 of 30]
Period:
Taohong Siwu decoction
Postmenstrual period:
Xiaoyao Granule
Intermenstrual period:
Zuogui pill plus Chinese honeylocust spine (Zao jiao ci)
Premenstrual period:
Wuzi Yanzong decoction combined with Erxian decoction plus Fluorite (Zi shi ying), fruit of beautiful sweetgum (Lu lu tong), deglued antler powder (Lu jiao shuang), and Indianmulberry (Ba ji tian)
Not mentioned drop-out rate
Small sample size

122RCT160Treatment arm: CHM + COH
Control arm: COH
Treatment arm: PR, 63.5% [40 of 63]
Control arm: PR, 41.5% [27 of 65]
Follicular phase:
Yueju pill combined with Wuwei Tiaojing Granule
Ovulation phase:
Bushen Cupailuan decoction
Luteal phase:
Yulin Zhu combiner with Xiaoyao Granule
Day 1-day 14 of ET:
Yulin Zhu combiner with Xiaoyao Granule
Confirmed pregnancy:
Yulin Zhu combiner with Xiaoyao Granule
Not mentioned blindness
Small sample size

123RCT100Treatment arm: CHM + COH
Control arm: COH
Treatment arm: PR, 50% [25 of 50]
Control arm: PR, 32% [16 of 50]
The basic prescription:
Prepared rehmannia root (Shu di), Chinese angelica root (Dang gui), Buckhorn (Lu jiao), Tortoise plastron (Gui jia), Achyranthes root (Huai niu xi), Motherwort fruit (Chong wei zi), Ganoderma lucidum (Ling zhi), Fruit of barbary wolf berry (Gou qi zi), Dodder (Tu si zi), Bighead atractylodes rhizome (Huai shan yao), Epimeddium (Xian ling pi), Pseudostellaria root (Tai zi shen), Red sage root (Dan shen), Anemarrhena (Zhi mu), Bark of amur corktree (Huang bai), and Dried human placemta (Zi he che)
Follicular phase:
Prepared rehmannia root (Shu di), Chinese angelica root (Dang gui), Fruit of barbary wolf berry (Gou qi zi), Epimeddium (Xian ling pi), Indianmulberry (Ba ji tian), Buckhorn (Lu jiao), Love ipea seed (Tao ren), Safflower (Hong hua), and Cyperirhizome (Xiang fu)
Luteal phase:
Dodder (Tu si zi), Indianmulberry (Ba ji tian), and Buckhorn (Lu jiao)
Not mentioned blindness
and drop-out rate
Small sample size

125RCT58Treatment arm: CHM + COH
Control arm: COH
Treatment arm: PR, 26.7% [8 of 30]
Control arm: PR, 21.4% [6 of 28]
Follicular phase:
Motherowrt fruit (Chong wei zi), Red peony root (Chi shao), Fruit of beautiful sweetgum (Lu lu tong), Love ipea seed (Tao ren), Safflower (Hong hua), Achyranthes root (Niu xi), Chinese angelica root (Dang gui), Red sage root (Dan shen), Cyperirhizome (Xiang fu), Lindera aggregate (Wu yao), Alisma rhizome (Ze xie), and Seed of cow-fat (Wang bu liu xing)
Ovulation phase:
Fruit of glossy privet (Nv zhen zi), Chinese angelica root (Sang gui), Yeradetajo (Han lian cao), Red sage root (Dan shen), Cyperirhizome (Xiang fu), Aucklandia root (Mu xiang), Lindera aggregate (Wu yao), and Alisma rhizome (Ze xie)
Luteal phase:
Cassia twig (Gui zhi), Epimeddium (Xian ling pi), Glue of tortoise plastrom (Gui ban jiao), Love ipea seed (Tao ren), Safflower (Hong hua), Chinese angelica root (Dang gui), Ed sage root (Dan shen), Cyperirhizome (Xiang fu), Aucklandia root (Mu xiang), Lindera aggregate (Wu yao), and Alisma rhizome (Ze xie)
Not mentioned blindness
and drop-out rate
Small sample size

126RCT42Treatment arm: CHM + COH
Control arm: COH
Treatment arm: PR, 38.1% [8 of 21]
Control arm: PR, 19.1% [4 of 21]
Follicular phase:
Pilose asiabell root (Dang shen), Bighead atractylodes rhizome (Shan yao), Motherowrt fruit (Chong wei zi), Dodder (Tu si zi), Salvia (Dan shen), Cyperirhizome (Xiang fu), Fleece-flower root (He shou wu), Fruit of glossy privet (Nv zhen zi),Prepared rehmannia root (Shu di huang), and Broomrape (Rou cong rong)
Ovulatory phase:
Ed sage root (Dan shen), Red peony root (Chi shao), Dogwood (Shan zhu yu), Lycopus herb (Ze lan), Cyperirhizome (Xiang fu), Fruit of glossy privet (Nv zhen zi), Dodder (Tu si zi), Aucklandia root (Mu xiang), and Lindera aggregate (Wu yao)
Luteal phase:
Glue of tortoise plastrom (Gui ban jiao), Dodder (Tu si zi), Loranthus (Sang ji sheng), Broomrape (Rou cong rong), Hinalayan teasel (Xu duan), Epimeddium (xian ling pi), Cyperirhizome (Xiang fu), Curculigo rhizome (Xian mao), and Indianmulberry (Ba ji tian)
Not mentioned blindness
and drop-out rate
Small sample size

127RCT53Treatment arm: CHM + COH
Control arm: COH
Treatment arm: PR, 48.0% [12 of 25]
Control arm: PR, 32.1% [9 of 28]
The basic prescription:
Dodder (Tu si zi), Loranthus (Sang ji sheng), Red peony root (Chi shao), Chinese angelica root (Dang gui), Ed sage root (Dan shen), Cyperirhizome (Xiang fu), Notoginseng (San qi), and Gallus gallus (Ji nei jin)
Follicular phase:
the basic prescription add Fruit of barbary wolf berry (Gou qi zi), Lilyturf root (Mai dong), Zedoary (E zhu), and Leonurus heterophyllus (Yi mu cao)
Ovulatory phase:
the basic prescription add herb of diverse wormwood
(Liu ji nu), Fruit of beautiful sweetgum (Lu lu tong), and Astragalus root (Huang qi)
Luteal phase:
the basic prescription add Indianmulberry (Ba ji tian), Fruit of glossy privet (Nv zhen zi), and Prepared rehmannia root (Shu di huang)
Not mentioned blindness
and drop-out rate
Small sample size

128Observational studies480Treatment arm: CHM PR, 10.8% [52 of 480]Period:
Cyperirhizome (Xiang fu), Root-bark of peony (Mu dan pi), Fruit of hawthorn (Shan zha), Red sage root (Dan shen), Red peony root (Chi shao), Atractylodes rhizome (Zhi cang zhu), Faces of flying squirrel (Wu ling zhi), Leonurus heterophyllus (Yi mu cao), Indian bread (Fu ling), and Dipsacus root (Chuan duan)
Follicular phase:
Chinese angelica root (Dang gui), Red peony root (Chi shao), Root of herbaceous peony (Bai shao), Cyperirhizome (Zhi xiang fu), Bighead atractylodes rhizome (Shan yao), Dogwood (Shan zhu yu), Oyster (Mu li), Indian bread (Fu ling), Alisma rhizome (Ze xie), Dipsacus root (Chuan duan), Loranthus (Sang ji sheng), and Fruit of hawthorn (Shan zha)
Ovulatory phase:
Chinese angelica root (Dang gui), Red peony root (Chi shao), Root of herbaceous peony (Bai shao, Bighead atractylodes rhizome (Shan yao), Dogwood (Shan zhu yu), Root-bark of peony (Dan pi), Indian bread (Fu ling), Dipsacus root (Chuan duan), Buckhorn (Lu jiao), Faces of flying squirrel (Wu ling zhi), Safflower (Hong hua), and Rhizome of Sichuan lovage (Chuan xiong)
Luteal phase:
Chinese angelica root (dang gui), Root of herbaceous peony (Bai shao), Bighead atractylodes rhizome (Shan yao), Root-bark of peony (Dan pi), Indian bread (Fu ling), Dipsacus root (Chuan duan), Buckhorn (Lu jiao), Fluorite (Zi shi ying), Taurus (Jin ling zi), Corydalis tuber (Yan hu suo), and Fruit of hawthorn (Shan zha)
No control group
Not mentioned drop-out rate

Note: CHM: Chinese herbal medicine; COH: control ovarian hyperstimulation; PR: pregnancy rate; versus treatment arm.

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