Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 429256, 8 pages
http://dx.doi.org/10.1155/2014/429256
Research Article

Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid from Kalanchoe pinnata

1Laboratory of Pharmacology, Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, BR 465, Km 07, 23890-000 Seropédica, RJ, Brazil
2Núcleo de Pesquisa de Produtos Naturais, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, 21941-902 Cidade Universitária, RJ, Brazil
3Universidade Federal de Goiás, Instituto de Ciências Biológicas, Departamento de Ciências Fisiológicas, 74001-970 Goiânia, GO, Brazil

Received 30 July 2014; Revised 2 November 2014; Accepted 6 November 2014; Published 11 December 2014

Academic Editor: Jae Youl Cho

Copyright © 2014 Raquel Teixeira Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. S. M. Bopda, F. Longo, T. N. Bella et al., “Antihypertensive activities of the aqueous extract of Kalanchoe pinnata (Crassulaceae) in high salt-loaded rats,” Journal of Ethnopharmacology, vol. 153, no. 2, pp. 400–407, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. E. F. Aransiola, M. O. Daramola, E. O. Iwalewa, A. M. Seluwa, and O. O. Olufowobi, “Anti-diabetic effect of Bryophyllum pinnatum leaves,” International Journal of Biological, Life Science and Engineering, vol. 8, no. 1, pp. 51–55, 2014. View at Google Scholar
  3. S. S. Costa, M. F. Muzitano, L. M. M. Camargo, and M. A. S. Coutinho, “Therapeutic potential of Kalanchoe species: flavonoids and other secondary metabolites,” Natural Product Communications, vol. 3, no. 12, pp. 2151–2164, 2008. View at Google Scholar · View at Scopus
  4. R. Milad, S. El-Ahmady, and A. N. Singab, “Genus Kalanchoe (Crassulaceae): a review of its ethnomedicinal, botanical, chemical and pharmacological properties,” European Journal of Medicinal Plants, vol. 4, no. 1, pp. 86–104, 2014. View at Publisher · View at Google Scholar
  5. C. Aoki, S. Hartati, M. R. Santi et al., “Isolation and identification of substances with anti-hepatitis c virus activities from Kalanchoe pinnata,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 2, pp. 211–215, 2014. View at Google Scholar · View at Scopus
  6. E. A. Cruz, S. Reuter, H. Martin et al., “Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease,” Phytomedicine, vol. 19, no. 2, pp. 115–121, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Hema, M. Tidjani, E. Bsssene, L. Posset, and H. Giono-Barber, “Plantes médicinales africaines XXIV étude de l’action anti-inflammatoire de Bryophyllum pinnatum (Crassulaceae),” Plantes Médicinales et Phytothérapie, vol. 20, no. 3, pp. 231–235, 1986. View at Google Scholar
  8. J. A. O. Ojewole, “Antinociceptive, anti-inflammatory and antidiabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract,” Journal of Ethnopharmacology, vol. 99, no. 1, pp. 13–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. P. J. C. Sousa, J. C. S. Rocha, A. M. Pessoa, L. A. D. Alves, and J. C. T. Carvalho, “Preliminar study of the anti-inflammatory activity of Bryophillum calycinum Salisb,” Revista Brasileira de Farmacognosia, vol. 15, no. 1, pp. 60–64, 2005. View at Google Scholar
  10. M. A. S. Coutinho, M. F. Muzitano, E. A. Cruz et al., “Flowers from Kalanchoe pinnata are a rich source of T cell-suppressive flavonoids,” Natural Product Communications, vol. 7, no. 2, pp. 175–178, 2012. View at Google Scholar · View at Scopus
  11. E. Middleton Jr., C. Kandaswami, and T. C. Theoharides, “The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer,” Pharmacological Reviews, vol. 52, no. 4, pp. 673–751, 2000. View at Google Scholar · View at Scopus
  12. A. B. Dongmo, T. Miyamoto, K. Yoshikawa, S. Arihara, and M.-A. Lacaille-Dubois, “Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities,” Planta Medica, vol. 73, no. 11, pp. 1202–1207, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Takano-Ishikawa, M. Goto, and K. Yamaki, “Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: comparison between subclasses of flavonoids,” Phytomedicine, vol. 13, no. 5, pp. 310–317, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-C. Chen, M.-P. Chow, W.-C. Huang, Y.-C. Lin, and Y.-J. Chang, “Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: structure-activity relationships,” Molecular Pharmacology, vol. 66, no. 3, pp. 683–693, 2004. View at Google Scholar · View at Scopus
  15. K. Morikawa, M. Nonaka, M. Narahara et al., “Inhibitory effect of quercetin on carrageenan-induced inflammation in rats,” Life Sciences, vol. 74, no. 6, pp. 709–721, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Peluso, A. Raguzzini, and M. Serafini, “Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: a systematic review and meta-analysis,” Molecular Nutrition & Food Research, vol. 57, no. 5, pp. 784–801, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. P. J. Vacher, P. Duchéne-Marullaz, and P. Barbot, “A propos de quelques produits usuels—comparaison de deux méthodes d'étude des analgésiques,” Medicina Experimentalis, vol. 11, pp. 51–58, 1964. View at Google Scholar
  18. D. B. M. Barbosa, M. V. M. Nascimento, R. C. Lino et al., “Mechanism involved in the anti-infl amatory effect of Spiranthera odoratissima (Manacá),” Brazilian Journal of Pharmacognosy, vol. 22, no. 1, pp. 137–143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. G. F. Passos, E. S. Fernandes, F. M. da Cunha et al., “Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea,” Journal of Ethnopharmacology, vol. 110, no. 2, pp. 323–333, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. J.-M. Cherng, W. Chiang, and L.-C. Chiang, “Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids,” Food Chemistry, vol. 106, no. 3, pp. 944–950, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Morikawa, M. Nonaka, M. Narahara et al., “Inhibitory effect of quercetin on carrageenan-induced inflammation in rats,” Life Sciences, vol. 74, no. 6, pp. 709–721, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. C. Bischoff, “Quercetin: potentials in the prevention and therapy of disease,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, no. 6, pp. 733–740, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. A. P. Rogerio, A. Kanashiro, C. Fontanari et al., “Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma,” Inflammation Research, vol. 56, no. 10, pp. 402–408, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. M. P. Nair, S. Mahajan, J. L. Reynolds et al., “The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κβ system,” Clinical and Vaccine Immunology, vol. 13, no. 3, pp. 319–328, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. J. H. Kwon, J. H. Kim, S. E. Choi, K. H. Park, and M. W. Lee, “Inhibitory effects of phenolic compounds from needles of Pinus densiflora on nitric oxide and PGE2 production,” Archives of Pharmacal Research, vol. 33, no. 12, pp. 2011–2016, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Ichikawa, M. Ogura, and T. Iijima, “Antiallergic flavone glycoside from Kalanchoe pinnatum,” JP Patent 61,118, 396, 1986. View at Google Scholar
  27. L. R. Ballou, R. M. Botting, S. Goorha, J. Zhang, and J. R. Vane, “Nociception in cyclooxygenase isozyme-deficient mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 18, pp. 10272–10276, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. Z. Parveen, Y. Deng, M. K. Saeed, R. Dai, W. Ahamad, and Y. H. Yu, “Antiinflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside,” Yakugaku Zasshi, vol. 127, no. 8, pp. 1275–1279, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. A. Zakaria, H. K. Gopalan, H. Zainal et al., “Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models,” Yakugaku Zasshi, vol. 126, no. 11, pp. 1171–1178, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. P. V. Afonso, M. Janka-Junttila, Y. J. Lee et al., “LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis,” Developmental Cell, vol. 22, no. 5, pp. 1079–1091, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. T. S. Fröde, G. E. P. Souza, and J. B. Calixto, “The modulatory role played by TNF-α and IL-1β in the inflammatory responses induced by carrageenan in the mouse model of pleurisy,” Cytokine, vol. 13, no. 3, pp. 162–168, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. M.-J. Sanz and P. Kubes, “Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking,” European Journal of Immunology, vol. 42, no. 2, pp. 278–283, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. H. N. Lee, H. J. Cho, D. Y. Lim, Y.-H. Kang, K. W. Lee, and J. H. Y. Park, “Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages,” International Journal of Molecular Sciences, vol. 14, no. 6, pp. 10926–10943, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Afzal, G. Gupta, I. Kazmi et al., “Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum,” Fitoterapia, vol. 83, no. 5, pp. 853–858, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. C. M. Lima, A. K. Lima, M. G. D. Melo et al., “Bioassay-guided evaluation of Dioscorea villosa—an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach,” BMC Complementary and Alternative Medicine, vol. 13, article 195, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. Q.-S. Wang, L. Yang, W.-Y. Cui, L. Chen, and Y.-H. Jiang, “Anti-inflammatory and anti-nociceptive activities of methanol extract from aerial part of Phlomis younghusbandii Mukerjee,” PLoS ONE, vol. 9, no. 3, Article ID e89149, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Darshika Kodithuwakku, M. Pan, Y.-L. Zhu et al., “Anti-inflammatory and antinociceptive effects of Chinese medicine SQ gout capsules and its modulation of pro-inflammatory cytokines focusing on gout arthritis,” Journal of Ethnopharmacology, vol. 150, no. 3, pp. 1071–1079, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. A. D. Mancini and J. A. Di Battista, “The cardinal role of the phospholipase A2/cyclooxygenase-2/ prostaglandin e synthase/prostaglandin E2 (PCPP) axis in inflammostasis,” Inflammation Research, vol. 60, no. 12, pp. 1083–1092, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Hämäläinen, R. Nieminen, M. Z. Asmawi, P. Vuorela, H. Vapaatalo, and E. Moilanen, “Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages,” Planta Medica, vol. 77, no. 13, pp. 1504–1511, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Koeberle, J. Bauer, M. Verhoff, M. Hoffmann, H. Northoff, and O. Werz, “Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E2 synthase-1,” Biochemical and Biophysical Research Communications, vol. 388, no. 2, pp. 350–354, 2009. View at Publisher · View at Google Scholar · View at Scopus