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| Study and setting | Types of cancer | Participants | Chemotherapy agents | Intervention | Control | Outcomes |
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S
a1: You et al. 2013 [24]
RCT, Zhejiang Cancer Hospital, Hangzhou, China | Nonsmall cell lung cancer | Randomized = 120, completed = 120,
intervention group: 60,
control group: 60 | Etoposide + cisplatin | Auricular acupressure + antiemetic medications (not specified) | Antiemetic medications
(not specified) | (i) CINV
(ii) Abdominal bloating
(iii) Abdominal pain
(iv) Blood glucose and insulin
(v) Anxiety
(vi) Depression
(vii) Pain intensity |
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S2: Yang and Liang 2013 [25]
RCT, The Second Affiliated Hospital of SUCM, Xianyang, China | Leukemia | Randomized = 58, completed = 58,
M/F = 23/35, age (yr) = 20–67
intervention group: 38,
control group: 20 | Cytarabine,
homoharringtonine,
daunorubicin,
cyclophosphamide,
mitoxantrone | Auricular acupressure + antiemetic medication (granisetron, 3 mg, IV, qd) | Antiemetic medication (granisetron, 3 mg, IV, qd) | CINV |
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S3: Li 2013 [26]
RCT, The first Affiliated Hospital of Soochow University, Suzhou, China | Lung cancer
Breast cancer
Ovarian cancer
Cervical cancer
Esophagus cancer
Nasopharynx cancer | Randomized = 32, completed = 32,
intervention group: 16, M/F = 5/11, age (yr) = 37–65,
control group: 16, M/F = 4/12, age (yr) = 36–67 | Combined chemotherapy based on cisplatin or Pharmorubicin | Auricular Acupressure + antiemetic medications
(azasetron, 10 mg, IV, qd + dexamethasone, 10 mg, IV, qd) | Antiemetic medications
(azasetron, 10 mg, IV, qd + dexamethasone, 10 mg, IV, qd) | CINV |
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S4: Fang 2013 [27]
RCT, Jiangyan TCM Hospital, Taizhou, China | Lung cancer
Liver cancer
Breast cancer
Colon cancer
Esophagus cancer
Nasopharynx cancer | Randomized = 100, completed = 100,
M/F = 42/58, age (yr) = 35–75
intervention group: 50,
control group: 50 | Not reported | Auricular acupressure + usual care | Usual care | CINV |
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S5: Zhang et al. 2013 [28]
RCT, Hangzhou TCM Hospital,
Hangzhou, China | Breast cancer | Randomized = 80, completed = 80,
intervention group: 40, age (yr) = 29–65 (mean: 47)
control group: 40, age (yr) = 32–67 (Mean: 48) | Not reported | Auricular acupuncture + antiemetic medications
(tropisetron, 5 mg, IV, qd) | Antiemetic medications
(tropisetron, 5 mg, IV, qd) | CINV |
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S6: Yeh et al. 2012 [29]
RCT (Crossover Design), A Large Children’s Hospital, Taiwan | Pediatric cancers | Randomized = 10, completed = 10,
M/F = 6/4, age (yr) = 13.29 ± 3.31 (range from 6 to 18)
Intervention group: NR
control group: NR
(crossover after 1st treatment) | Cyclophosphamide | Auricular acupressure + antiemetic medications
(ondansetron or granisetron + dexamethasone) | Auricular acupressure using sham acupoints +
antiemetic medications
(ondansetron or granisetron + dexamethasone) | (i) CINV
(ii) Adverse events
(iii) Booklet used to record intensity and duration of acupressure technique |
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S7: Zhang et al. 2012 [30]
RCT, The First Affiliated Hospital of GUCM, Guangzhou, China | Acute leukemia | Randomized = 100, completed = 100,
intervention group: 50, M/F = 24/26, age (yr) = 45 ± 14.8 (range from 17 to 64),
control group: 50, M/F = 23/27, age (yr) = 44 ± 15.2 (range from 14 to 62) | DA combination (daunorubicin + cytarabine) or VP combination (vincristine + prednisone) | Auricular acupressure + antiemetic medications
(ondansetron, 8 mg, IV, qd) | Antiemetic medications
(ondansetron, 8 mg, IV, qd) | (i) CINV
(ii) Food intake |
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S8: Jiang 2012 [31]
RCT, Zhejiang Cancer Hospital, Hangzhou, China | Not specified | Randomized = 85, completed = 85,
intervention group: 43, M/F = 27/16, age (yr) = 36 to 75,
control group: 42, M/F = 25/17, age (yr) = 33 to 72 | Combined chemotherapy based on cisplatin or Adriamycin | Auricular Acupressure + Antiemetic Medication (Granisetron, 8 mg, IV, qd) | Antiemetic medication (granisetron, 8 mg, IV, qd) | (i) CINV
(ii) Adverse events |
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S9: Zhong et al. 2012 [32]
RCT (Crossover Design), The First Hospital of Wuhan, Wuhan, China | Lung cancer
Breast cancer
Gastric cancer
Colon cancer
Ovarian cancer
Cervical cancer
Tongue cancer
Endometrial cancer
Nasopharynx cancer | Randomized = 100, completed = 94,
M/F = 58/42, age (yr) = 17–70 (mean: 52.3)
intervention group: NR
control group: NR
(crossover after 1st treatment) | GP combination (gemcitabine + cisplatin) or TP combination (docetaxel + cisplatin) or AC combination (Adriamycin + cyclophosphamide) or DF combination (cisplatin + fluorouracil), and so forth. | Auricular acupressure + antiemetic medications
(tropisetron, qd + diphenhydramine, qd + dexamethasone, qd) | Antiemetic medications
(tropisetron, qd + diphenhydramine, qd + dexamethasone, qd) | (i) CINV
(ii) Constipation |
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S10: Lu 2012 [33]
RCT, Ningbo TCM Hospital of Zhejiang Province, Ningbo, China | Breast cancer | Randomized = 128, completed = 128,
intervention group: 64, age (yr) = 45.10 ± 10.42,
control group: 64, age (yr) = 52.96 ± 6.11 | CAF combination (cyclophosphamide + Adriamycin + fluorouracil) or CMF combination (cyclophosphamide + methotrexate + fluorouracil) | Auricular acupressure + antiemetic medication (granisetron, 3 mg, IV, qd) | Antiemetic medication (granisetron, 3 mg, IV, qd) | CINV |
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S11: Huang et al. 2012 [34]
RCT, The First Hospital of Wuhan, Wuhan, China | Breast cancer | Randomized = 80, completed = 80, age (yr) = 28–65 (mean: 46.5)
intervention group: 40,
control group: 40 | Anthracycline-based combination | Auricular acupressure + antiemetic medications
(tropisetron, 4 mg, IV, bid) | Antiemetic medications
(tropisetron, 4 mg, IV, bid) | (i) CINV
(ii) Constipation |
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S12: Wang 2012 [35]
RCT, Xuzhou TCM Hospital of Jiangsu Province, Xuzhou, China | Breast cancer | Randomized = 52, completed = 52, age (yr) = 47.4 (mean)
intervention group: 26,
control group: 26 | Cyclophosphamide or fluorouracil or Adriamycin or taxol or doxorubicin or Navelbine | Auricular acupressure + antiemetic medications
(azasetron, 10 mg, IV + omeprazole, 40 mg, IV) | Antiemetic medications
(azasetron, 10 mg, IV + omeprazole, 40 mg, IV) | (i) CINV
(ii) Constipation
(iii) Abdominal bloating
(iv) Abdominal pain
(v) Headache |
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S13: Huang 2011 [36]
RCT, The First Hospital of Shangqiu City, Shangqiu, China | Lung cancer
Gastric cancer
Colon cancer
Breast cancer | Randomized = 120, completed = 120,
M/F = 70/50, age (yr) = 30–76
intervention group: 60,
control group: 60 | Not reported | Auricular acupressure + antiemetic medications
(azasetron) | Antiemetic medications
(azasetron) | (i) CINV
(ii) Physical performance status |
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S14: Liu and Chen 2011 [37]
RCT, The First Affiliated Hospital of GUCM, Guangzhou, China | Lung cancer | Randomized = 127, completed = 127,
intervention group: 85, M/F = 53/32, age (yr) = 56 ± 11.4 (range from 31 to 75),
control group: 42, M/F = 23/19, age (yr) = 51 ± 10.9 (range from 35 to 75) | Platinum-based chemotherapy | Auricular acupressure + antiemetic medications
(granisetron, 3 mg, IV, bid or ondansetron, 8 mg, IV, bid) | Antiemetic medications
(granisetron, 3 mg, IV, bid or ondansetron, 8 mg, IV, bid) | (i) CINV
(ii) Physical performance status |
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S15: Ye et al. 2011 [38]
RCT, The General Hospital of Chinese People's Liberation Army, Beijing, China | Not specified | Randomized = 47, completed = 47,
intervention group: 27, M/F = 15/12, age (yr) = 58 ± 12 (range from 33 to 76),
control group: 20, M/F = 11/9, age (yr) = 57 ± 11 (range from 40 to 78) | Not reported | Auricular acupressure + antiemetic medications
(tropisetron, 4 mg, IV, bid) | Auricular acupressure using sham acupoints +
antiemetic medications
(tropisetron, 4 mg, IV, bid) | (i) CINV
(ii) Constipation |
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S16: Bi 2011 [39]
RCT, LongHua Hospital Affiliated to SUTCM, Shanghai, China | Gastrointestinal cancer | Randomized = 50, completed = 50, M/F = 23/27, age (yr) = 45.27
intervention group: 25,
control group: 25 | Cisplatin + fluorouracil | Auricular acupressure + antiemetic medications
(ondansetron, basic dose: 8 mg, IV, qd) | Antiemetic medications
(ondansetron, basic dose: 8 mg, IV, qd) | Use of antiemetic medications |
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S17: Luo 2011 [40]
RCT, The First Affiliated Hospital of GUCM, Guangzhou, China | Lung cancer
Colon cancer
Breast cancer
Gastric cancer
Ovarian cancer
Nasopharynx cancer | Randomized = 50, completed = 50,
age (yr) = 20 to 80 (mean: 52.24 ± 10.75)
Intervention group: 26, M/F = 12/14,
Control group: 24, M/F = 9/15 | Platinum-based chemotherapy | Auricular acupressure + antiemetic medications
(granisetron, 3 mg, IV, bid) | Antiemetic medications
(granisetron, 3 mg, IV, bid) | (i) CINV
(ii) Adverse events
(iii) Clinical symptoms
(iv) Physical performance status |
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S18: Jing 2007 [41]
RCT, Jiangsu Province Hospital of TCM, Nanjing, China | Not specified | Randomized = 54, completed = 54,
intervention group: 30, M/F = 20/10, age (yr) = 47.65
control group: 24, M/F = 16/8, age (yr) = 47.59 | Platinum-based chemotherapy | Auricular acupressure + antiemetic medications
(ondansetron, 8 mg, IV, qd) | Antiemetic medications
(ondansetron, 8 mg, IV, qd) | CINV |
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S19: Qian et al. 2006 [42]
RCT, LongHua Hospital Affiliated to SUTCM, Shanghai, China | Lung cancer
Breast cancer
Gastrointestinal cancer | Randomized = 67, completed = 67, M/F = 35/32, age (yr) = 39–77
intervention group: 36,
control group: 31 | Combined chemotherapy based on cisplatin or fluorouracil | Auricular acupressure + antiemetic medications
(ondansetron, 8 mg, IV, qd) | Antiemetic medications
(ondansetron, 8 mg, IV, qd) | CINV |
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S20: Zhang et al. 2003 [43]
RCT, LongHua Hospital Affiliated to SUTCM, Shanghai, China | Respiratory cancer
Gastrointestinal cancer | Randomized = 173, completed = 173,
intervention group: 70, M/F = 28/42, age (yr) = 25–78,
control group 1: 50, M/F = 19/31, age (yr) = 24–77,
control group 2: 53, M/F = 23/30, age (yr) = 26–76 | MVP combination (mitomycin + vindesine + cisplatin) or NP combination (Navelbine + cisplatin) or FAM combination (fluorouracil + Adriamycin + mitomycin), and so forth. | Auricular acupressure | Control group 1:
antiemetic medications
(ondansetron, 8 mg, IV, qd)
Control group 2:
antiemetic medications
(metoclopramide, 20 mg, IM, qd) | CINV |
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S21: Sun 2003 [44]
RCT, The Affiliated Hospital of SDUTCM, Jinan, China | Breast cancer | Randomized = 80, completed = 80,
intervention group: 40, age (yr) = 41.5,
control group: 40, age (yr) = 42.3 | Not reported | Auricular acupressure | Antiemetic medications
(metoclopramide, 30 mg, IV) | CINV |
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