Synergistic Effect between Cryptotanshinone and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus

Table 1

Antibacterial activity of cryptotanshinone and antibiotics in isolated MRSA, VRSA, MSSA, and some of reference bacteria.

Samples	Cryptotanshinone (μg/mL)			Ampicillin	Oxacillin	Vancomycin
	MIC50<	MIC90<	MIC/MBC	MIC/MBC (μg/mL)
MSSA ATCC 25923^1	4	64	64/256	8/16	0.25/1	0.5/2
MRSA ATCC 33591^2	0.5	4	4/16	512/2048	8/16	1/4
VRSA 3A063^3	0.5	2	2/4	512/2048	512/1024	16/32
VRSA 3A066^4	1	4	4/16	128/256	512/1024	32/64
MSSA 1^5	2	16	16/64	1024/2048	0.5/1	1/4
MSSA 2^6	8	32	32/128	256/512	1/2	1/2
MRSA 1	2	16	16/32	128/256	128/256	1/2
MRSA 2	8	64	64/128	256/256	8/32	2/4
MRSA 3	1	4	4/16	128/512	128/512	2/4
MRSA 4	0.5	4	4/8	128/256	512/2048	1/2
MRSA 5	2	64	64/128	128/512	512/1024	1/2
MRSA 6	0.5	4	4/16	64/128	64/256	1/2
MRSA 7	2	8	8/16	128/256	512/1024	1/4
MRSA 8	4	32	32/64	256/256	512/2048	1/4
MRSA 9	2	8	8/16	64/128	512/1024	1/2
MRSA 10	2	16	16/64	128/256	512/1024	1/2
MRSA 11	4	8	8/32	64/128	64/128	1/2
MRSA 12	1	4	4/8	128/256	128/256	1/4
MRSA 13	4	32	32/128	128/256	32/128	1/2
MRSA 14	0.5	8	8/16	64/128	8/16	1/4
MRSA 15	0.5	4	4/16	64/128	128/256	1/4
MRSA 16	2	8	8/16	128/512	128/512	1/2

 ¹MSSA (ATCC 25923): reference strain methicillin-sensitive Staphylococcus aureus.
²MRSA (ATCC 33591): reference strain methicillin-resistant Staphylococcus aureus.
³VRSA 3A063: vancomycin-resistant Staphylococcus aureus isolated clinically.
⁴VRSA 3A066: vancomycin-resistant Staphylococcus aureus isolated clinically.
⁵MSSA (1-2): methicillin-sensitive Staphylococcus aureus isolated clinically.
⁶MRSA (1–16): methicillin-resistant Staphylococcus aureus isolated clinically.