Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 465640, 8 pages
http://dx.doi.org/10.1155/2014/465640
Research Article

Guanxinkang Decoction Exerts Its Antiatherosclerotic Effect Partly through Inhibiting the Endoplasmic Reticulum Stress

1Department of Traditional Chinese Medicine, The First Hospital of Shijiazhuang City, 36 Fanxi Road, Shijiazhuang, Hebei 050011, China
2First Hospital of Shijiazhuang and Organ Transplantation Committee in Chinese Medical Association, 36 Fanxi Road, Shijiazhuang, Hebei 050011, China

Received 7 November 2013; Revised 10 March 2014; Accepted 10 March 2014; Published 18 May 2014

Academic Editor: Joen-Rong Sheu

Copyright © 2014 Hao Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. B. Fallon, Y. Ben-Shlomo, P. Elwood, J. B. Ubbink, and G. Davey Smith, “Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow up,” Heart, vol. 85, no. 2, pp. 153–158, 2001. View at Google Scholar · View at Scopus
  2. T. Suhara, K. Fukuo, O. Yasuda et al., “Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways,” Hypertension, vol. 43, no. 6, pp. 1208–1213, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Feng, Z. Zhang, W. Kong, B. Liu, Q. Xu, and X. Wang, “Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/-mice,” Cardiovascular Research, vol. 84, no. 1, pp. 155–163, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. W. Eikelboom, E. Lonn, J. Genest Jr., G. Hankey, and S. Yusuf, “Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence,” Annals of Internal Medicine, vol. 131, no. 5, pp. 363–375, 1999. View at Google Scholar · View at Scopus
  5. H. J. Blom, H. A. Kleinveld, G. H. J. Boers et al., “Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia,” European Journal of Clinical Investigation, vol. 25, no. 3, pp. 149–154, 1995. View at Google Scholar · View at Scopus
  6. A. Tawakol, T. Omland, M. Gerhard, J. T. Wu, and M. A. Creager, “Hyperhomocyst(e)inemia is associated with impaired endothelium- dependent vasodilation in humans,” Circulation, vol. 95, no. 5, pp. 1119–1121, 1997. View at Google Scholar · View at Scopus
  7. N. Tyagi, A. V. Ovechkin, D. Lominadze, K. S. Moshal, and S. C. Tyagi, “Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia,” Journal of Cellular Biochemistry, vol. 98, no. 5, pp. 1150–1162, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Kotamraju, E. A. Konorev, J. Joseph, and B. Kalyanaraman, “Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species,” Journal of Biological Chemistry, vol. 275, no. 43, pp. 33585–33592, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Abdelfatah, D. Ducloux, G. Toubin, G. Motte, D. Alber, and J.-M. Chalopin, “Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients,” Transplantation, vol. 73, no. 4, pp. 663–665, 2002. View at Google Scholar · View at Scopus
  10. M. Crompton, “The mitochondrial permeability transition pore and its role in cell death,” The Biochemical Journal, vol. 341, part 2, pp. 233–249, 1999. View at Google Scholar · View at Scopus
  11. D. Kumar and B. I. Jugdutt, “Apoptosis and oxidants in the heart,” Journal of Laboratory and Clinical Medicine, vol. 142, no. 5, pp. 288–297, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. H. L. Pahl, “Signal transduction from the endoplasmic reticulum to the cell nucleus,” The Physiological Reviews, vol. 79, no. 3, pp. 683–701, 1999. View at Google Scholar · View at Scopus
  13. W. Xin, X. Li, X. Lu, K. Niu, and J. Cai, “Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia,” International Journal of Molecular Medicine, vol. 27, no. 4, pp. 503–509, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. A. S. Lee, “The glucose-regulated proteins: stress induction and clinical applications,” Trends in Biochemical Sciences, vol. 26, no. 8, pp. 504–510, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. P. A. Outinen, S. K. Sood, S. I. Pfeifer et al., “Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells,” Blood, vol. 94, no. 3, pp. 959–967, 1999. View at Google Scholar · View at Scopus
  16. D. Ron, “Hyperhomocysteinemia and function of the endoplasmic reticulum,” The Journal of Clinical Investigation, vol. 107, no. 10, pp. 1221–1222, 2001. View at Google Scholar · View at Scopus
  17. F.-R. Chen, N. Zhang, P. Liu, Y.-Y. Zhang, X.-H. Han, and J.-F. Cai, “Effects of Guanxinkang on expressions of ATP-sensitive potassium channel subunits Kir6.1, Kir6.2, SUR2A and SUR2B in ischemic myocytes of rats,” Journal of Chinese Integrative Medicine, vol. 8, no. 5, pp. 458–464, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M.-J. Mao, J.-P. Hu, F.-R. Chen, Y.-Y. Zhang, and P. Liu, “Effects of Chinese herbal medicine Guanxinkang on lipid metabolism and serum C-reactive protein, amyloid A protein and fibrinogen in apolipoprotein E-knockout mice with atherosclerosis,” Journal of Chinese Integrative Medicine, vol. 9, no. 3, pp. 306–312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. J. Mao, J. P. Hu, C. Wang, Y. Y. Zhang, and P. Liu, “Effects of Chinese herbal medicine Guanxinkang on expression of PPARgamma-LXRalpha-ABCA1 pathway in ApoE-knockout mice with atherosclerosis,” Journal of Chinese Integrative Medicine, vol. 10, pp. 814–820, 2012. View at Google Scholar
  20. N. Zhang, E. R. Chen, and Y. Y. Zhang, “Effect of Guanxinkang on ATP-sensitive potassium channel in myocardial cells of rat with ischemic/ reperfusion injury,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 30, pp. 1186–1189, 2010. View at Google Scholar
  21. “What is atherosclerosis?” http://www.webmd.com/heart-disease/what-is-atherosclerosis.
  22. K. S. McCully, “Hyperhomocysteinemia and arteriosclerosis: historical perspectives,” Clinical Chemistry and Laboratory Medicine, vol. 43, no. 10, pp. 980–986, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Zeng, J. Dai, D. G. Remick, and X. Wang, “Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes,” Circulation Research, vol. 93, no. 4, pp. 311–320, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Bertolotti, Y. Zhang, L. M. Hendershot, H. P. Harding, and D. Ron, “Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response,” Nature Cell Biology, vol. 2, no. 6, pp. 326–332, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Paschen and T. Mengesdorf, “Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease-therapeutic potential,” Pharmacology and Therapeutics, vol. 108, no. 3, pp. 362–375, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Szegezdi, S. E. Logue, A. M. Gorman, and A. Samali, “Mediators of endoplasmic reticulum stress-induced apoptosis,” EMBO Reports, vol. 7, no. 9, pp. 880–885, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Dobos and I. Tao, “The model of western integrative medicine: the role of Chinese medicine,” Chinese Journal of Integrative Medicine, vol. 17, no. 1, pp. 11–20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Robinson, “Integrative medicine—traditional Chinese medicine, a model?” Chinese Journal of Integrative Medicine, vol. 17, no. 1, pp. 21–25, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Xu and K.-J. Chen, “Integrating traditional medicine with biomedicine towards a patient-centered healthcare system,” Chinese Journal of Integrative Medicine, vol. 17, no. 2, pp. 83–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. J.-W. Xu, “Advancements on the pharmaceutical effcts of radix salviae miltiorrhizae,” Medical Review Journal, vol. 12, pp. 1467–1468, 2006. View at Google Scholar
  31. L. Li and J. Yi, “Effects of radix astragali on the growth of the endothelial progenitor cells of athersclerotic rabbits,” Practical Medical Journal, pp. 1154–1156, 2011. View at Google Scholar
  32. P. Zhang, Therapeutics of Intigrated Traditional Chinese and Western Medicines on Hyperlipemia, 2001.
  33. X. Li and R. Zhang, “Effects of extracts of radix salviae miltiorrhizae on experimental prevention of arterial re-stenosis,” Traditional Chinese Herbs Journal, vol. 29, pp. 255–257, 2004. View at Google Scholar
  34. Z. Wang and N.-N. Xu, “Effects of extracts of radix salviae miltiorrhizae on the glucolipid metabolism of shrews with hyperlipemia,” Shizhen Journal of Traditional Chinese Medicine and Herbs, pp. 1067–1069, 2009. View at Google Scholar