Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers

Table 1

Pharmacokinetic parameters of fexofenadine after a single dose administration of 60 mg fexofenadine in 12 healthy volunteers before and after multiple-dose coadministration of danshen ethanol extract.

PK parameter	Control	Multiple dose	Ratio to control (multiple doses)
(ng/mL)	223.92 ± 74.36	148.05 ± 60.93^*	0.65 (0.51–0.83)
(h)	3 (1.5–6.0)	2.0 (0.5–3.0)	—
(ng·h/mL)	1612.23 ± 773.58	844.57 ± 339.67^*	0.55 (0.42–0.71)
(ng·h/mL)	1717.66 ± 815.21	889.99 ± 353.11^*	0.54 (0.41–0.70)
(h)	5.97 ± 0.82	5.96 ± 1.00	0.99 (0.89–1.11)
CL/F (L/h)	44.35 ± 25.57	77.88 ± 31.20^*	1.86 (1.43–2.42)

Data are presented as mean ± SD. Data of ratio to control are shown as mean (95% confidence interval); data are shown as median (range).
^* values are given for the differences with respect to control.