The Immunological Enhancement Activity of Propolis Flavonoids Liposome In Vitro and In Vivo

Figure 3

The dynamic change of spleen lymphocyte proliferation in synergistic stimulation of drugs with PHA () (a) and LPS () (b) after vaccination. ICR mouse was inoculated twice on days 0 and 14 with OVA encapsulated in propolis flavonoids liposome, blank liposome, and Freund’s Complete Adjuvant or mixed in propolis flavonoids and the proliferation rates of spleen lymphocyte mix with PHA or LPS were measured on weeks 0, 1, 2, 3, 4, 5, and 6 after first vaccination. Values are mean ± SEM, mice/group. The superscripts without the same letters near the curves differ significantly () from each other in the same week group.

(a)

(b)