Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil

Table 3

Analegsia effect of the pain induced by hot-plate in mice (𝑥±𝑠, 𝑛=10).

Group	Dosage (mg/kg)	Pain threshold of preadmin/s	Pain threshold of proadmin/s
			15 min	30 min	60 min	90 min	120 min
NS		19.6 ± 5.8	19.3 ± 5.5	19.9 ± 5.3	20.3 ± 5.1	20.5 ± 5.5	19.8 ± 5.4
EOZ low-dose	20 mg	19.8 ± 4.7	20.5 ± 5.8③	20.9 ± 6.1③	20.8 ± 5.8③	20.8 ± 6.2③	20.5 ± 5.6③
EOZ middle-dose	40 mg	19.7 ± 4.8	23.9 ± 6.5③	31.4 ± 6.3①	32.2 ± 7.1①	34.8 ± 7.2①	34.6 ± 6.9①
EOZ high-dose	80 mg	19.7 ± 5.3	24.5 ± 5.6③	35.2 ± 5.3②	37.5 ± 6.1②	38.1 ± 5.6②	37.8 ± 5.3②
Ver	5 mg	20.3 ± 3.2	20.6 ± 5.2③	20.9 ± 6.1③	19.8 ± 6.4	21.5 ± 6.2③	21.6 ± 6.6③
EOZ + Ver low-dose	20 mg + 5 mg	20.5 ± 4.1	25.8 ± 6.6③	32.2 ± 5.7②④	33.5 ± 5.2②④	34.8 ± 5.9②④	35.5 ± 6.2②④
EOZ + Ver middle-dose	40 mg + 5 mg	19.6 ± 5.1	25.4 ± 5.2③	37.4 ± 5.3②④	40.6 ± 6.1②④	40.7 ± 6.1②④	41.5 ± 7.0②④
EOZ + Ver high-dose	80 mg + 5 mg	19.8 ± 4.8	26.2 ± 8.2③	41.2 ± 6.8②④	45.2 ± 6.8②④	46.7 ± 6.5②④	45.8 ± 7.2②④
Mor	10 mg	19.8 ± 4.6	45.3 ± 6.7②	46.8 ± 7.2②	45.3 ± 7.1②	24.9 ± 5.6③	21.7 ± 4.9③

Compared with NS group: ①: 𝑃<0.05, ②: 𝑃<0.01, ③: 𝑃>0.05; compared with relevant EOZ group: ④: 𝑃<0.01.