Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil

Table 4

Effect of the tail-curling latencies of mice in the warm water tail-flick test (𝑥±𝑠, 𝑛=10).

Group	Dosage (mg/kg)	Basal TFL/s	TFL of proadmin/s
			15 min	30 min	60 min	90 min	120 min
NS		3.42 ± 0.52	3.48 ± 0.61	3.51 ± 0.72	3.62 ± 0.89	3.46 ± 0.61	3.48 ± 0.63
EOZ low-dose	20 mg	3.52 ± 0.68	3.72 ± 0.79③	4.16 ± 0.97③	4.25 ± 0.92③	4.20 ± 0.91③	4.25 ± 0.92③
EOZ middle-dose	40 mg	3.45 ± 0.62	4.15 ± 0.67③	4.85 ± 0.78①	5.01 ± 0.88①	5.12 ± 0.75①	5.12 ± 0.85①
EOZ high-dose	80 mg	3.50 ± 0.58	4.14 ± 0.85③	5.23 ± 0.82②	5.41 ± 0.76②	5.42 ± 0.83②	5.41 ± 0.86②
Ver	5 mg	3.49 ± 0.78	3.50 ± 0.75③	3.51 ± 0.82③	3.41 ± 0.84③	3.54 ± 8.6③	3.48 ± 0.85③
EOZ + Ver low-dose	20 mg + 5 mg	3.38 ± 0.72	4.56 ± 0.76③	6.85 ± 0.78②④	7.22 ± 0.75②④	7.34 ± 0.85②④	6.46 ± 0.78②④
EOZ + Ver middle-dose	40 mg + 5 mg	3.32 ± 0.65	4.12 ± 0.78③	9.23 ± 0.66②④	9.54 ± 0.78②④	9.68 ± 0.82②④	9.57 ± 0.65②④
EOZ + Ver high-dose	80 mg + 5 mg	3.47 ± 0.60	4.11 ± 0.73③	11.2 ± 0.78②④	12.4 ± 0.85②④	13.1 ± 0.87②④	12.5 ± 0.91②④
Mor	10 mg	3.56 ± 0.63	13.68 ± 0.86②	12.62 ± 0.76②	11.42 ± 0.79②	8.49 ± 0.88②	5.52 ± 0.82②

Compared with NS group: ①: 𝑃<0.05, ②: 𝑃<0.01, ③: 𝑃>0.05; compared with EOZ group: ④: 𝑃<0.05.