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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 506273, 8 pages
Research Article

Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi

1Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rodovia Araraquara-Jaú, km 1, 14 800 901 Araraquara, SP, Brazil
2Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rua Professor Francisco Degni, 55, Bairro Quitandinha, 14800-060 Araraquara, SP, Brazil

Received 11 June 2014; Revised 13 October 2014; Accepted 28 October 2014; Published 20 November 2014

Academic Editor: José L. Ríos

Copyright © 2014 Ana Carolina Alves de Paula e Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.