Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice

Figure 3

Effect of HTPE on total protein concentration in the BALF of LPS-induced ALI mice. Mice were administered, via the oral and intraperitoneal routes, HTPE (0.1–1 g/kg) and dexamethasone (DEX: 5 mg/kg, positive control group), respectively, 1 h before intranasal administration of LPS (10 μg/site). Vehicle (VH: tap water, vehicle for HTPE) was also administered orally 1 h before intranasal administration of LPS (LPS group) or saline (vehicle for LPS, negative control group). BALF was collected 6 h after LPS challenge to measure total protein concentration. Values are presented as the mean and SEM (𝑛=6 for VH or HTPE; 𝑛=4 for DEX). ^#𝑃<0.05 versus negative control group (VH + saline), ^∗𝑃<0.05 versus LPS group (VH + LPS) (Holm-Sidak multiple comparisons).