Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 543606, 11 pages
http://dx.doi.org/10.1155/2014/543606
Research Article

Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3k/Akt Insulin Signaling Pathway

1Institute of Biosciences, São Paulo State University (UNESP), 18618-970 Botucatu, SP, Brazil
2Department of Biological Sciences, Faculty of Sciences, São Paulo State University (UNESP), 17033-360 Bauru, SP, Brazil
3Department of Physical Education, Faculty of Sciences, São Paulo State University (UNESP), Avenida Engenheiro Luiz Edmundo Carrijo Coube, 14-01, 17033-360 Bauru, SP, Brazil

Received 21 January 2014; Accepted 3 April 2014; Published 27 April 2014

Academic Editor: Chong-Zhi Wang

Copyright © 2014 Priscilla Maria Ponce Vareda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Diabetes Association, “Diagnosis and classification of Diabetes mellitus,” Diabetes Care, vol. 34, supplement 1, pp. S62–S69, 2011. View at Publisher · View at Google Scholar
  2. Sociedade Brasileira de Diabetes (SBD), Diretrizes da Sociedade Brasileira de Diabetes, 2009, http://www.diabetes.org.br/attachments/diretrizes09_final.pdf.
  3. A. Y. Y. Cheng and I. G. Fantus, “Oral antihyperglycemic therapy for type 2 Diabetes mellitus,” Canadian Medical Association Journal, vol. 172, no. 2, pp. 213–226, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. J. K. Grover, S. Yadav, and V. Vats, “Medicinal plants of India with anti-diabetic potential,” Journal of Ethnopharmacology, vol. 81, no. 1, pp. 81–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Kumar, R. Ilavarasan, T. Jayachandra et al., “Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats,” Journal of Medicinal Plants Research, vol. 2, no. 9, pp. 246–249, 2008. View at Google Scholar
  6. P. G. Wilson, M. M. O'Brien, P. A. Gadek, and C. J. Quinn, “Myrtaceae revisited: a reassessment of infrafamilial groups,” American Journal of Botany, vol. 88, no. 11, pp. 2013–2025, 2001. View at Google Scholar · View at Scopus
  7. M. D. De Cerqueira, E. J. De Marques, D. Martins, N. F. Roque, F. G. Cruz, and M. L. D. S. Guedes, “Seasonal variation of the composition of essential oil from Myrcia salzmannii berg. (myrtaceae),” Quimica Nova, vol. 32, no. 6, pp. 1544–1548, 2009. View at Google Scholar · View at Scopus
  8. E. M. Russo, A. A. Reichelt, J. R. De-Sa et al., “Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients,” Brazilian Journal of Medical and Biological Research, vol. 23, no. 1, pp. 11–20, 1990. View at Google Scholar · View at Scopus
  9. G. Hashimoto, Illustrated Cyclopedia of Brazilian Medicinal Plants, Aboc-Sha, Kamakura, Japan, 1996.
  10. L. I. F. Jorge, J. P. L. Aguiar, and M. L. Silva, “Anatomia foliar de pedra-hume-caá (Myrcia sphaerocarpa, Myrcia guianensis, Eugia punicifolia-Myrtaceae),” Acta Amazonica, vol. 30, pp. 49–57, 2000. View at Google Scholar
  11. M. Yoshikawa, H. Shimada, N. Nishida et al., “Antidiabetic principles of natural medicines. lI. Aldose reductase and α-glucosidase inhibitors from brazilian natural medicine, the leaves of Myrcia multiflora DC. (Myrtaceae): structures of myrciacitrins I and II and myrciaphenones A and B,” Chemical and Pharmaceutical Bulletin, vol. 46, no. 1, pp. 113–119, 1998. View at Google Scholar · View at Scopus
  12. R. P. Limberger, M. Sobral, A. T. Henriques, C. Menut, and J. Bessière, “Essential oils from Myrcia species native to Rio Grande do Sul,” Quimica Nova, vol. 27, no. 6, pp. 916–919, 2004. View at Google Scholar · View at Scopus
  13. H. Matsuda, T. Morikawa, and M. Yoshikawa, “Antidiabetogenic constituents from several natural medicines,” Pure and Applied Chemistry, vol. 74, no. 7, pp. 1301–1308, 2002. View at Google Scholar · View at Scopus
  14. H. Matsuda, N. Nishida, and M. Yoshikawa, “Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): structures of myrciacitrins III, IV, and V,” Chemical and Pharmaceutical Bulletin, vol. 50, no. 3, pp. 429–431, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. L. L. Saldanha, W. Vilegas, and A. L. Dokkedal, “Characterization of flavonoids and phenolic acids in Myrcia bella Cambess. Using FIA-ESI-IT-MSn and HPLC-PAD-ESI-IT-MS combined with NMR,” Molecules, vol. 18, no. 7, pp. 8402–8416, 2013. View at Publisher · View at Google Scholar
  16. A. S. Brito, Manual de Ensaios Toxicológicos, Ciências Médicas, Campinas, Brazil, 1995.
  17. A. Rafacho, L. P. Roma, S. R. Taboga, A. C. Boschero, and J. R. Bosqueiro, “Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets,” Canadian Journal of Physiology and Pharmacology, vol. 85, no. 5, pp. 536–545, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Szkudelski, “The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas,” Physiological Research, vol. 50, no. 6, pp. 537–546, 2001. View at Google Scholar · View at Scopus
  19. M. T. Pepato, J. R. Oliveira, I. C. Kettelhut, and R. H. Migliorini, “Assessment of the antidiabetic activity of Myrcia uniflora extracts in streptozotocin diabetic rats,” Diabetes Research, vol. 22, no. 2, pp. 49–57, 1993. View at Google Scholar · View at Scopus
  20. E. Middleton Jr., C. Kandaswami, and T. C. Theoharides, “The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer,” Pharmacological Reviews, vol. 52, no. 4, pp. 673–751, 2000. View at Google Scholar · View at Scopus
  21. K. C. Ong and H. Khoo, “Effects of myricetin on glycemia and glycogen metabolism in diabetic rats,” Life Sciences, vol. 67, no. 14, pp. 1695–1705, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Vessal, M. Hemmati, and M. Vasei, “Antidiabetic effects of quercetin in streptozocin-induced diabetic rats,” Comparative Biochemistry and Physiology-C Toxicology and Pharmacology, vol. 135, no. 3, pp. 357–364, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. I.-M. Liu, S. Liou, T. Lan, F. Hsu, and J. Cheng, “Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats,” Planta Medica, vol. 71, no. 7, pp. 617–621, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. L. W. Qi, E.-H. Liu, C. Chu, Y. Peng, H. Cai, and P. Li, “Anti-diabetic agents from natural products-an update from 2004 to 2009,” Current Topics in Medicinal Chemistry, vol. 10, no. 4, pp. 434–457, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Jung, M. Park, H. C. Lee, Y. Kan, E. S. Kang, and S. K. Kim, “Antidiabetic agents from medicinal plants,” Current Medicinal Chemistry, vol. 13, no. 10, pp. 1203–1218, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. C. S. Jiang, L. F. Liang, and Y. W. Guo, “Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades,” Acta Pharmacologica Sinica, vol. 33, pp. 1217–1245, 2012. View at Publisher · View at Google Scholar
  27. J. B. C. Carvalheira, H. G. Zecchin, and M. J. A. Saad, “Insulin signaling pathways,” Arquivos Brasileiros de Endocrinologia & Metabologia, vol. 46, no. 4, pp. 419–425, 2002. View at Publisher · View at Google Scholar
  28. S. Lehto, T. Rönnemaa, S. M. Haffner, K. Pyörälä, V. Kallio, and M. Laakso, “Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM,” Diabetes, vol. 46, no. 8, pp. 1354–1359, 1997. View at Google Scholar · View at Scopus
  29. K. Rahman, “Studies on free radicals, antioxidants, and co-factors,” Clinical Interventions in Aging, vol. 2, no. 2, pp. 219–236, 2007. View at Google Scholar · View at Scopus
  30. W. C. Dornas, T. T. Oliveira, R. G. Rodrigues-das-Dores, A. F. Santos, and T. J. Nagem, “Flavonoids: therapeutic potential against oxidative stress,” Revista de Ciencias Farmaceuticas Basica e Aplicada, vol. 28, no. 3, pp. 241–249, 2007. View at Google Scholar · View at Scopus
  31. C. G. Wang, S. R. Mehendale, T. Calway, and C. S. Yuan, “Botanical flavonoids on coronary heart disease,” American Journal of Chinese Medicine, vol. 39, no. 4, pp. 661–671, 2011. View at Publisher · View at Google Scholar · View at Scopus