Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells

Table 2

The cytotoxic effects of cisplatin combined with AE-CA or CPT in HEC-1A and HEC-1B cells. The data described in Figure 5 were analyzed to obtain combination drug indices (CDI), using the CalcuSyn software to determine whether the effects of the combination treatments demonstrated a synergistic effect (CDI < 1), an additive effect (CDI = 1), or an antagonistic effect (CDI > 1).

Combination of AE-CA or CPT	HEC-1A		HEC-1B
	AE-CA	CPT	AE-CA	CPT
Cisplatin(μM)
1	0.201	0.163	0.605	0.635
5	0.116	0.161	0.173	0.165
10	0.177	0.256	0.254	0.237
20	0.284	0.388	0.522	0.464
30	0.382	0.488	0.814	0.761
40	0.464	0.533	1.081	1.021
50	0.563	0.623	1.375	1.316