Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 1

Body weight values of Sprague-Dawley rats orally treated with Polygala tenuifolia extracts in acute oral toxicity study.

Group summary of body weight
Dosage in days	(Vehicle-treated group, 0 g/10 mL/kg/B.W.)		(Test substance-treated group, 2 g/10 mL/kg/B.W.)
	Mean ± S.D.		Mean ± S.D.
Male
−1	212.70 ± 2.955	5	240.20 ± 2.953	5
0	193.53 ± 2.767	5	191.71 ± 3.125	5
1	218.14 ± 1.530	5	192.55^*  ± 13.589	5
7	277.23 ± 8.416	5	255.49^*  ± 15.501	5
14	328.20 ± 19.827	5	313.22 ± 13.880	5
Female
−1	197.17 ± 4.587	5	197.16 ± 4.621	5
0	163.89 ± 5.228	5	159.58 ± 4.439	5
1	181.93 ± 8.6178	5	163.81^*  ± 10.634	4
7	215.62 ± 14.040	5	203.59 ± 11.938	4
14	235.38 ± 21.433	5	231.21 ± 6.933	4

S.D.: Standard deviation.
: Number of animals.
^*P 0.05 compared to the vehicle-treated group.
(Unit: g).