Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 11

Serum biochemical values (mean ± standard deviation) of female rats in the subchronic oral dose toxicity study of the root of Polygala tenuifolia.

Parameter	Dose (mg/kg/day)
	0	360	600	1,000
Number of animals examined	10	10	10	10
AST (IU/L)	91.1 ± 14.0	94.0 ± 17.8	85.9 ± 16.7	86.8 ± 14.0
ALT (IU/L)	35.5 ± 5.8	34.5 ± 4.1	32.9 ± 5.1	32.6 ± 5.3
ALP (IU/L)	64.1 ± 14.9	74.8 ± 9.9	73.8 ± 20.8	71.2 ± 10.1
BUN (mg/dL)	19.3 ± 3.0	17.2 ± 1.9	17.4 ± 1.9	18.4 ± 1.6
CRE (mg/dL)	0.65 ± 0.07	0.64 ± 0.06	0.66 ± 0.11	0.67 ± 0.09
GLU (mg/dL)	116.2 ± 12.7	119.2 ± 11.6	111.7 ± 7.3	110.4 ± 11.0
CHO (mg/dL)	97.2 ± 17.7	106.3 ± 16.7	112.9 ± 19.4	120.4 ± 15.1
PRO (g/dL)	6.23 ± 0.15	6.36 ± 0.29	6.23 ± 0.32	6.11 ± 0.19
CPK (IU/L)	134.8 ± 60.9	120.2 ± 84.3	115.9 ± 82.1	121.9 ± 63.4
ALB (g/dL)	3.23 ± 0.09	3.31 ± 0.15	3.26 ± 0.15	3.20 ± 0.12
BIL (mg/dL)	0.20 ± 0.02	0.21 ± 0.02	0.21 ± 0.03	0.21 ± 0.02
TG (mg/dL)	43.9 ± 5.2	42.9 ± 7.5	52.8 ± 16.3	47.8 ± 8.3
IP (mg/dL)	6.00 ± 0.85	6.15 ± 1.22	6.42 ± 0.99	6.46 ± 0.45
Ca^2+ (mg/dL)	9.61 ± 0.13	9.78 ± 0.46	9.71 ± 0.17	9.63 ± 0.15
A/G (ratio)	1.08 ± 0.05	1.09 ± 0.08	1.10 ± 0.07	1.11 ± 0.08
Na^+ (mmol/L)	143.3 ± 1.06	143.6 ± 0.97	142.7 ± 1.06	142.5 ± 1.20
K^+ (mmol/L)	4.24 ± 0.19	4.57 ± 1.25	4.15 ± 0.27	4.24 ± 0.18
Cl^− (mmol/L)	108.3 ± 1.16	109.1 ± 1.20	109.6 ± 0.84	109.88 ± 1.64
	10	10	10	8