Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 13

Absolute and relative organ weight of females in the subchronic oral dose toxicity study of the root of Polygala  tenuifolia.

Parameter	Dose (mg/kg/day)
	0	360	600	1,000
Body weight	260.11 ± 15.83	259.59 ± 6.80	253.95 ± 17.41	250.61 ± 7.87
Ovary, left (g)	0.0505 ± 0.0119	0.0547 ± 0.0081	0.0467 ± 0.0138	0.0537 ± 0.0067
Per body weight (%)	0.0193 ± 0.0040	0.0211 ± 0.0031	0.0183 ± 0.0045	0.0214 ± 0.0025
Ovary, right	0.0532 ± 0.0072	0.0526 ± 0.0064	0.0515 ± 0.0092	0.0538 ± 0.0058
Per body weight (%)	0.0204 ± 0.0025	0.0203 ± 0.0026	0.0203 ± 0.0032	0.0215 ± 0.0024
Adrenal gland, left	0.0332 ± 0.0073	0.0339 ± 0.0030	0.0324 ± 0.0052	0.0370 ± 0.0041
Per body weight (%)	0.0128 ± 0.0025	0.0131 ± 0.0010	0.0128 ± 0.0020	0.0148 ± 0.0019
Adrenal gland, right	0.0279 ± 0.0044	0.0309 ± 0.0046	0.0301 ± 0.0036	0.0319 ± 0.0068
Per body weight (%)	0.0107 ± 0.0016	0.0119 ± 0.0017	0.0119 ± 0.30015	0.0128 ± 0.0029
Pituitary gland	0.0148 ± 0.0053	0.0137 ± 0.0011	0.0134 ± 0.0015	0.0141 ± 0.0019
Per body weight (%)	0.0056 ± 0.0016	0.0053 ± 0.0004	0.0053 ± 0.0004	0.0056 ± 0.0009
Thymus	0.2235 ± 0.0323	0.2292 ± 0.0349	0.2243 ± 0.0232	0.2290 ± 0.0320
Per body weight (%)	0.0863 ± 0.0142	0.0882 ± 0.0127	0.0883 ± 0.0068	0.0915 ± 0.0128
Uterus	0.6040 ± 0.1695	0.5195 ± 0.1438	0.4848 ± 0.1573	0.6109 ± 0.3313
Per body weight (%)	0.2347 ± 0.0730	0.2002 ± 0.0548	0.1929 ± 0.0678	0.2436 ± 0.1313
Spleen	0.5954 ± 0.596	0.5786 ± 0.0512	0.5402 ± 0.1754	0.6280 ± 0.3671
Per body weight (%)	0.2287 ± 0.0147	0.2228 ± 0.0174	0.2111 ± 0.0673	0.2506 ± 0.1340
Kidney, left	0.7683 ± 0.0657	0.7544 ± 0.0510	0.7713 ± 0.1081	0.7513 ± 0.4212
Per body weight (%)	0.2953 ± 0.0162	0.2905 ± 0.0164	0.3049 ± 0.0495	0.3000 ± 0.1856
Kidney, right	0.7547 ± 0.0548	0.7553 ± 0.0511	0.7900 ± 0.1248	0.7618 ± 0.4748
Per body weight (%)	0.2898 ± 0.0117	0.2909 ± 0.0178	0.3124 ± 0.0572	0.3041 ± 0.1993
Heart	0.9126 ± 0.0678	0.8911 ± 0.0619	0.9117 ± 0.1012	0.9030 ± 0.6912
Per body weight (%)	0.3511 ± 0.0197	0.3433 ± 0.0225	0.3588 ± 0.0280	0.3607 ± 0.3053
Lung	1.4077 ± 0.0881	1.4371 ± 0.0983	1.4229 ± 0.2161	1.4301 ± 0.9812
Per body weight (%)	0.5418 ± 0.0275	0.5535 ± 0.0329	0.5628 ± 0.1006	0.5704 ± 0.3008
Brain	1.8129 ± 0.0649	1.8308 ± 0.0685	1.8026 ± 0.0750	1.8440 ± 0.5932
Per body weight (%)	0.6982 ± 0.0274	0.7058 ± 0.0358	0.7123 ± 0.0485	0.7367 ± 0.3932
Liver	6.0596 ± 0.2314	6.3790 ± 0.6585	6.4577 ± 0.5182	6.4618 ± 0.4515
Per body weight (%)	2.3339 ± 0.0996	2.4553 ± 0.2191	2.5459 ± 0.1755	2.5778 ± 0.1469^*
	10	10	10	8

Body weight before necropsy and after fasting.
^*Significant difference at P < 0.05 compared with the vehicle-treated group.