Research Article
Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs
Table 2
Incidence of clinical signs of male beagle dogs orally treated with Polygala tenuifolia extracts in single dose oral toxicity study.
| Sex: male | Day | Signs observed | Group | 0 | 1,000 | 2,000 |
| 0-1 (0.5 hours) | Appears normal | 2/2* | 2/2 | 0/2 | Vomiting (severe) | 0/2 | 0/2 | 2/2 | 0–2 (1 hour) | Appears normal | 2/2 | 2/2 | 2/2 | 0–3 (2 hours) | Appears normal | 2/2 | 2/2 | 2/2 | 0–4 (3 hours) | Appears normal | 2/2 | 1/2 | 2/2 | Vomiting (mild) | 0/2 | 1/2 | 0/2 | 0–5 (4 hour) | Appears normal | 2/2 | 2/2 | 2/2 | 0–6 (5 hours) | Appears normal | 2/2 | 1/2 | 2/2 | Vomiting (food) | 0/2 | 1/2 | 0/2 | 0–7 (6 hours) | Appears normal | 2/2 | 2/2 | 2/2 | 1 | Appears normal | 2/2 | 2/2 | 2/2 | 2 | Appears normal | 2/2 | 2/2 | 2/2 | 3 | Appears normal | 2/2 | 2/2 | 2/2 | 4 | Appears normal | 2/2 | 2/2 | 2/2 | 5 | Appears normal | 2/2 | 2/2 | 1/2 | Vomiting (food) | 0/2 | 0/2 | 1/2 | 6 | Appears normal | 2/2 | 2/2 | 2/2 | 7 | Appears normal | 2/2 | 2/2 | 2/2 | 8 | Appears normal | 2/2 | 2/2 | 2/2 | 9 | Appears normal | 2/2 | 2/2 | 2/2 | 10 | Appears normal | 2/2 | 2/2 | 2/2 | 11 | Appears normal | 2/2 | 2/2 | 2/2 | 12 | Appears normal | 2/2 | 2/2 | 2/2 | 13 | Appears normal | 2/2 | 2/2 | 2/2 | 14 | Appears normal | 2/2 | 2/2 | 2/2 |
|
|
Number of animals with the sign/number of animals examined.
|