Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 4

Body weight values of beagle dogs orally treated with Polygala tenuifolia extracts in single dose oral toxicity study.

Sex: male
Group	Body weights (kg)
(mg/kg)	Animal ID	0 d	1 d	3 d	7 d	14 d	Gain
0; ()	1	7.283	7.350	7.694	7.741	8.226	0.943
	2	8.075	8.043	8.097	8.185	8.448	0.373
	Mean	7.679 ± 0.560	7.697 ± 0.490	7.896 ± 0.285	7.963 ± 0.314	8.337 ± 0.157	0.658 ± 0.403
1,000; ()	3	8.785	8.549	8.666	8.551	8.938	0.153
	4	7.961	7.863	8.128	8.068	8.352	0.391
	Mean	8.373 ± 0.583	8.206 ± 0.485	8.397 ± 0.380	8.310 ± 0.342	8.645 ± 0.414	0.272 ± 0.168
2,000; ()	5	8.282	8.225	8.437	8.511	8.918	0.636
	6	7.269	7.595	7.375	7.588	7.959	0.690
	Mean	7.776 ± 0.716	7.910 ± 0.445	7.906 ± 0.751	8.050 ± 0.653	8.439 ± 0.678	0.663 ± 0.038
Sex: female
Group	Body weights (kg)
(mg/kg)	Animal ID	0 d	1 d	3 d	7 d	14 d	Gain
0; ()	7	7.145	7.412	7.160	7.308	7.567	0.422
	8	6.531	6.656	6.291	6.875	7.159	0.628
	Mean	6.838 ± 0.434	7.034 ± 0.535	6.726 ± 0.614	7.092 ± 0.306	7.363 ± 0.288	0.525 ± 0.146
1,000; ()	9	7.433	7.465	7.417	7.395	7.307	−0.126
	10	7.046	6.474	6.658	6.660	6.930	−0.116
	Mean	7.240 ± 0.274	6.970 ± 0.701	7.038 ± 0.537	7.028 ± 0.520	7.119 ± 0.267	−0.121 ± 0.007
2,000; ()	11	7.449	7.138	7.238	7.245	7.534	0.085
	12	7.096	6.898	7.111	7.007	7.156	0.060
	Mean	7.273 ± 0.250	7.018 ± 0.170	7.175 ± 0.090	7.126 ± 0.168	7.345 ± 0.267	0.072 ± 0.018