Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 5

Gross findings of beagle dogs orally treated with Polygala tenuifolia extracts in single dose oral toxicity study.

Sex: male
Group	Gross observation		Frequency
(mg/kg)	Location	Gross findings	Death	Survivors
0		No gross findings	^*0/0	2/2
1,000		No gross findings	0/0	2/2
		No gross findings	0/0	0/2
2,000	Duodenum	Hemorrhage on mucous membrane	0/0	1/2
	Lung	Dark red discoloration of right lobule	0/0	1/2
Sex: female
Group	Gross observation		Frequency
(mg/kg)	Location	Gross findings	Death	Survivors
0		No gross findings	^*0/0	2/2
1,000		No gross findings	0/0	2/2
2,000		No gross findings	0/0	2/2

Number of animals with the sign/Number of animals examined.