Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 6

Food consumption of male rats.

Food consumption (g)
Study: 08-RR-011	Dose (mg/kg/day)				Sex: male
Weeks	0		360		600		1,000
	Mean ± S.D.		Mean ± S.D.		Mean ± S.D.		Mean ± S.D.
0	19.69 ± 0.65	10	19.25 ± 1.81	10	19.90 ± 1.17	10	20.65 ± 1.54	10
1	20.98 ± 1.49	10	20.96 ± 1.26	10	21.20 ± 1.31	10	20.78 ± 1.77	10
2	19.67 ± 1.52	10	21.09 ± 1.51	10	21.00 ± 0.74	10	21.13 ± 1.23	10
3	20.13 ± 1.27	10	21.77 ± 1.06	10	21.70 ± 1.86	10	20.44 ± 1.13	10
4	18.60 ± 0.80	10	20.84 ± 1.30^**	10	19.65 ± 0.84	10	19.06 ± 0.33	10
5	19.34 ± 0.59	10	20.27 ± 0.80	10	20.26 ± 1.66	10	19.78 ± 1.22	10
6	20.32 ± 0.78	10	20.41 ± 1.18	10	20.15 ± 0.95	10	19.02 ± 1.41	10
7	19.72 ± 0.44	10	19.85 ± 0.66	10	19.77 ± 0.87	10	18.72 ± 1.48	10
8	17.63 ± 0.69	10	18.61 ± 1.56	10	18.35 ± 1.74	10	18.27 ± 1.64	10
9	19.12 ± 1.79	10	19.95 ± 0.99	10	19.05 ± 0.56	10	18.39 ± 0.89	10
10	20.20 ± 1.23	10	21.53 ± 1.01^*	10	19.90 ± 0.85	10	18.97 ± 0.61	10
11	18.17 ± 0.41	10	19.11 ± 1.44	10	18.40 ± 1.54	10	17.62 ± 0.94	10
12	19.67 ± 1.31	10	20.64 ± 1.35	10	18.85 ± 1.19	10	19.96 ± 2.02	10
13	20.46 ± 1.27	10	21.80 ± 0.77	10	20.61 ± 2.73	10	21.73 ± 0.98	10

P < 0.05 and ^**P < 0.01 compared to the vehicle-treated group.