Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs
Table 9
Hematological values (mean ± standard deviation) of female rats in the subchronic oral toxicity study of the root of Polygala tenuifolia.
Parameter
Dose (mg/kg/day)
0
360
600
1,000
WBC (103/L)
4.60 ± 0.63
4.75 ± 0.94
5.52 ± 1.92
5.11 ± 0.79
RBC (106/L)
7.89 ± 0.23
7.98 ± 0.36
7.87 ± 0.38
7.78 ± 0.16
Hemoglobin (g/dL)
14.3 ± 0.6
14.7 ± 0.7
14.1 ± 0.6
14.6 ± 0.3
Hematocrit (%)
41.2 ± 1.3
42.1 ± 2.5
40.9 ± 1.9
41.9 ± 0.8
MCV (fL)
52.3 ± 2.0
52.8 ± 1.1
52.0 ± 1.6
53.9 ± 1.1
MCH (pg)
18.2 ± 0.9
18.5 ± 0.3
18.0 ± 0.7
18.8 ± 0.6
MCHC (g/L)
34.7 ± 0.7
35.0 ± 0.4
34.6 ± 0.5
34.9 ± 0.5
RDW (%)
10.8 ± 0.4
10.6 ± 0.3
10.8 ± 0.4
10.6 ± 0.3
HDW (g/dL)
2.28 ± 0.19
2.22 ± 0.13
2.21 ± 0.16
2.33 ± 0.15
Platelet (103/L)
1104.4 ± 103.0
1166.6 ± 89.7
1194.1 ± 166.4
1134.0 ± 88.3
MPV (fL)
6.9 ± 0.9
6.5 ± 0.44
7.0 ± 0.9
6.5 ± 0.6
Reticulocyte (%)
2.05 ± 0.60
1.91 ± 0.20
1.97 ± 0.32
2.08 ± 0.46
9
10
10
8
WBC: white blood cell count; RBC: red blood cell count; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin concentration; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; HDW: hemoglobin distribution width; MPV: mean platelet volume.
