Effect of Poria cocos on Puromycin Aminonucleoside-Induced Nephrotic Syndrome in Rats
Effect of WPC ameliorates renal morphology changes and inhibition of AQP2 trafficking. (a) Periodic acid-Schiff (PAS) staining of the cortex and (b) inner renal medulla in rat kidney sections. (c) Immunohistochemistry staining of AQP2 (shown in brown) in the kidney medullar. Representative histological sections of kidney medulla of Sham group, untreated PAN group, nephrotic rat treated with Losartan group (30 mg/kg/day), and nephrotic rat treated with WPC group (200 mg/kg/day). (d) Immunofluorescence staining of AQP2 in renal medulla. AQP2 trafficking was stained in rhodamine (red). Membrane was visualized by WGA (green) (magnification: 400x).
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