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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 586857, 8 pages
http://dx.doi.org/10.1155/2014/586857
Research Article

The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects

1Comprehensive Education Center for Community Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8575, Japan
2Department of Education and Support for Community Medicine, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan
3Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan
4Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan
5Division of General Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya Ward, Saitama City 330-8503, Japan

Received 21 February 2014; Accepted 22 March 2014; Published 24 April 2014

Academic Editor: Wei Jia

Copyright © 2014 Shin Takayama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to examine the effects of oral administration of kampo medical formulas on ocular blood flow (OBF). A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years). The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration. Blood pressure (BP) and intraocular pressure (IOP) were also recorded. No significant changes were observed in mean BP or IOP after the administration of any of the kampo medical formulas. There was a significant increase in OBF 30 minutes after administration of TSS (100% to 103.6 ± 6.9%, ). Next, TSS was administered to 19 healthy subjects (mean age: 32.0 ± 11.0 years) and OBF was measured before and 15, 30, 45, and 60 minutes after administration. Plain water was used as a control. OBF increased significantly after TSS administration compared to control ( ) and also increased from 30 to 60 minutes after administration compared to baseline ( ). These results suggest that TSS can increase OBF without affecting BP or IOP in healthy subjects.