The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects

Table 2

Alteration of IOP and systemic variables in response to administration of each kampo formula (Experiment  1).

	Variable	Baseline	30 minutes after treatment	𝑃 value
YKS	OBF change (%)	100.0±0.0	96.9±6.7	0.05
	IOP (mmHg)	12.9±2.5	13.0±2.9	0.73
	MBP (mmHg)	83.7±10.7	87.8±8.2	0.13
	PR (beats/min)	73.6±7.7	66.9±7.8	<0.01
TSS	OBF change (%)	100.0±0.0	103.6±6.9	<0.01
	IOP (mmHg)	14.2±2.4	14.1±2.5	0.98
	MBP (mmHg)	85.4±10.0	86.8±4.9	0.27
	PR (beats/min)	75.5±10.7	67.0±8.0	<0.01
KBG	OBF change (%)	100.0±0.0	101.8±6.9	0.35
	IOP (mmHg)	13.6±2.5	13.3±2.9	0.17
	MBP (mmHg)	86.0±9.0	86.9±8.9	0.74
	PR (beats/min)	71.0±8.2	66.6±7.9	0.05
HJG	OBF changc (%)	100.0±0.0	100.0±6.9	0.89
	IOP (mmHg)	13.2±2.7	13.1±2.5	0.81
	MBP (mmHg)	84.4±9.8	85.9±6.0	0.74
	PR (beats/min)	77.2±6.8	67.2±7.7	<0.01

Data are expressed as mean ± standard deviation. The Wilcoxon signed-rank test was applied to assess differences in the values before and after kampo administration.