Protective Effects of Bu-Shen-Huo-Xue Formula against 5/6 Nephrectomy-Induced Chronic Renal Failure in Rats

<table>BSHX downregulates the mRNA expression of TGF-<i>β </i><sub>1</sub> and CTGF in the renal tissue of 5/6 nephrectomy rats. Following eight weeks of treatment with BSHX at the doses of 0.25, 0.5, and 1.0 g/kg·d, the mRNA expression of TGF-<i>β </i><sub>1</sub> (a) and CTGF (b) in the renal tissue was analyzed by FQ-RT-PCR. <sup>ΔΔ</sup><svg height="11.375" id="M25" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with the sham group. <svg height="13.95" id="M26" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 73.300003 13.95" width="73.300003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with the control group. Data are expressed as the mean ± SD. <svg height="11.225" id="M27" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>.</table>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Protective Effects of Bu-Shen-Huo-Xue Formula against 5/6 Nephrectomy-Induced Chronic Renal Failure in Rats 