Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 2

Review Article

Mechanisms of Maggot-Induced Wound Healing: What Do We Know, and Where Do We Go from Here?

Table 2

Wound Healing results associated with selected published maggot therapy studies.

Pressure ulcer study1Diabetic ulcer study2
Conventional therapyMDTConventional therapyMDT

Quality of wound base
 Initial granulation tissue as % of total area31%27%1819
 Granulation tissue at 4 29%69%1556
 Percentage of wounds developing ≥ 50% granulation tissue1851
 Weeks until granulation tissue reached > 50%4.72.1
 Change in % of granulation tissue per week*3.30%13%
Wound size and healing
 Initial surface area in sq cm*1422.16.313.3
 Change in surface area during treatment 6.3−7.35−3.8
 Change in surface area per 1.4−1.51.15−0.78
 Percentage of wounds which decreased in size within 4 weeks*44%79%
 Healing rate at 4 −0.0380.101−0.080.08
 Healing rate at 8 −0.0270.096−0.020.07
 Percentage of wounds completely healed21%39%2136
 Average time to complete healing (weeks)13.4121815

Sherman, 2002 [18] (*identifies significantly different results between the two arms of this study); Sherman, 2003 [19] (+identifies significantly different results between the two arms of this study). The wound healing rate, based on studies by Gilman [69] and Margolis et al. [70], was defined as the change in surface area divided by the mean circumference over time. Study details provided in text.