Extracts and Fractions from Edible Roots of Sechium edule (Jacq.) Sw. with Antihypertensive Activity
Table 3
Antihypertensive effect produced by losartan (10 mg/kg) and fractions (50 mg/kg) obtained from SeRAce, on pretreated mice with AG II (1.0 g/kg, i.v. ).
Treatment
Systolic BP mmHg
Diastolic BP mmHg
Vehicle
127.51 ± 3.24
61.14 ± 6.74
AG II
146.40 ± 3.01
95.90 ± 8.01
R2
133.98 ± 15.86
86.3 ± 14.86
R5
122.61 ± 16.43
84.5 ± 18.08
R6
132.38 ± 17.87
93.03 ± 20.83
R8
138.01 ± 14.84
93.63 ± 13.98
R11
119.45 ± 19.85
82.07 ± 16.23
R14
109.21 ± 13.94*
68.88 ± 12.10*
R17
109.09 ± 8.73*
71.66 ± 14.53*
R20
122.55 ± 13.15
77.71 ± 10.97
Losartan
119.50 ± 11.73
77.45 ± 12.41
Data are presented as means ± SD with . ANOVA and post hoc Bonferroni test. is with respect to the negative control (AG II 1.0 g/kg).
