Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine

Figure 1

Inhibition mechanism of MTX in DNA synthesis pathway. MTX: methotrexate; FPGS: folylpolyglutamate synthetase; MTX-PGs: methotrexate polyglutamates; DHFR: dihydrofolate reductase; TS: thymidylate synthase; FH4: tetrahydrofolate; FH2: dihydrofolate; Methylene-THF: 5,10-methylenetetrahydrofolate; Methyl-THF: 5-methyltetrahydrofolate; dUMP: deoxyurindine-5′-monophosphate; dTMP: deoxythymidine-5′-monophosphate; MTRR: methionine synthase reductase; SHMT: serine hydroxymethyltransferase.