Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine

Table 3

Predicted pharmacokinetic properties of TCM candidates and MTX.

Index	TCM candidate	Pharmacokinetic properties
		Absorption	Solubility	Hepatotoxicity	PPB
1	Adenosine triphosphate	3	2	1	0
2	Chlorogenic acid	3	4	1	0
3	Cistanoside C	3	2	1	2
4	Forsythiaside	3	2	1	0
5	Isoacteoside	3	2	1	0
6	Isochlorogenic acid	3	4	1	0
7	Jionoside C	3	3	1	2
8	Jionoside D	3	2	1	2
9	Manninotriose	3	3	0	0
10	Methyl 4,6-di-O-galloyl-beta-D-glucopyranoside	3	2	1	0
11	Methyl 6-O-digalloyl-beta-D-glucopyranoside	3	2	1	0
12	Methyl 6-O-digalloyl-beta-D-glucopyranoside (II)	3	2	1	0
13	Methyl 3,3,6-tri-O-galloyl-beta-D-glucopyranoside	3	0	1	0
14	Raffinose	3	3	0	0
15	Rehmannioside A	3	4	1	0
16	Rehmannioside B	3	4	1	0
17	Rutin	3	1	1	2
18	Stachyose	3	1	0	0
Control	MTX	3	3	1	1

1Absorption (Human intestinal absorption), there are four prediction levels: 0 (good absorption), 1 (moderate absorption), 2 (poor absorption), 3 (very poor absorption).
²Solubility, there are gour prediction levels: 0 (extremely low), 1 (very low, but possible), 2 (low), 3 (good), 4 (optimal), 5 (too soluble), 6 (warning).
³Hepatotoxicity, there are four prediction levels: 0 (nontoxic), 1 (toxic).
⁴PPB (Plasma protein binding), there are there prediction levels: 0 (binding is <90%), 1 (binding is >90%), 2 (binding >95%).