Anticoagulant Activity of Polyphenolic-Polysaccharides Isolated from Melastoma malabathricum L.

Figure 1

Activated partial thromboplastin time (APTT) of Melastoma malabathricum Linn. leaf extract purified via solid phase extraction (SPE) into F1, F2, F3, and F4. Crude extract and fractions (1 mg/mL, 500 μg/mL, 250 μg/mL, and 125 μg/mL) were tested on human normal pooled plasma. Heparin sodium salt from porcine intestinal mucosa (140 USP units mg⁻¹) was used as a positive control. Data represent means ± S.E.M. of three independent experiments. Significant differences compared to the control group (normal pooled plasma with deionised water, vehicle) are designated as ^∗∗𝑃<0.05 and ^∗∗∗𝑃<0.001. NC: no coagulation.