Tetramethylpyrazine Protects against Hydrogen Peroxide-Provoked Endothelial Dysfunction in Isolated Rat Aortic Rings: Implications for Antioxidant Therapy of Vascular Diseases
Figure 1
Tetramethylpyrazine (TMP) protects against hydrogen peroxide- (H2O2-) induced endothelial dysfunction. Phenylephrine (Phe, 0.3 μM) was utilized to provoke contraction in isolated rat aortic rings, and acetylcholine (ACh, 3 nM–10 μM) was utilized to induce EDR in the Phe-contracted rings. (a) Representative traces of ACh-induced EDR in H2O2 (200 μM)-exposed rings, with and without TMP (10 nM) pretreatment, and control rings. (b), (c) Effects of various drug treatments on H2O2-provoked disruption of ACh-induced EDR. The graphs share the same data for the control and H2O2-treated groups. Data represent the mean ± the standard error of the mean (SEM) of 4–6 independent experiments ( versus control; versus H2O2).
