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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 627285, 9 pages
Research Article

Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats

1Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China
2The Affiliated Hospital to Changchun University of Chinese Medicine, Gongnong Road 1478, Changchun, Jilin 130021, China

Received 2 April 2014; Accepted 10 June 2014; Published 1 July 2014

Academic Editor: Tsung-Chieh Jackson Wu

Copyright © 2014 He Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Deer sinew (DS) has been used traditionally for various illnesses, and the major active constituent is collagen. In this study, we assessed the effects of collagen peptide from DS on bone loss in the ovariectomized rats. Wister female rats were randomly divided into six groups as follows: sham-operated (SHAM), ovariectomized control (OVX), OVX given 1.0 mg/kg/week nylestriol (OVX + N), OVX given 0.4 g/kg/day collagen peptide (OVX + H), OVX given 0.2 g/kg/day collagen peptide (OXV + M), and OVX given 0.1 g/kg/day collagen peptide (OXV + L), respectively. After 13 weeks of treatment, the rats were euthanized, and the effects of collagen peptide on body weight, uterine weight, bone mineral density (BMD), serum biochemical indicators, bone histomorphometry, and bone mechanics were observed. The data showed that BMD and concentration of serum hydroxyproline were significantly increased and the levels of serum calcium, phosphorus, and alkaline phosphatase were decreased. Besides, histomorphometric parameters and mechanical indicators were improved. However, collagen peptide of DS has no effect on estradiol level, body weight, and uterine weight. Therefore, these results suggest that the collagen peptide supplementation may also prevent and treat bone loss.