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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 628473, 8 pages
http://dx.doi.org/10.1155/2014/628473
Research Article

Antidiabetic Effects of Carassius auratus Complex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice

1Medical Center of Aging Research, China Medical University Hospital, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan
2School of Nutrition, Chung Shan Medical University, No. 110, Sec. 1, Chien Kuo North Road, Taichung, 40201, Taiwan
3Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien Kuo North Road, Taichung 40201, Taiwan
4School of Medical Laboratory and Biotechnology, Chung Shan Medical University, No. 110, Sec. 1, Chien Kuo North Road, Taichung 40201, Taiwan

Received 24 October 2013; Accepted 13 December 2013; Published 8 January 2014

Academic Editor: Bor-Show Tzang

Copyright © 2014 Zhi-Hong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Carassius auratus complex formula, including Carassius auratus, Rhizoma dioscoreae, Lycium chinense, and Rehmannia glutinosa Libosch, is a combination prescription of traditional Chinese medicine, which has always been used to treat diabetes mellitus in ancient China. In this study, we provided experimental evidence for the use of Carassius auratus complex formula in the treatment of high fat diet combined streptozotocin- (STZ-) induced type 2 diabetes. Carassius auratus complex formula aqueous extract was prepared and the effects of it on blood glucose, serum insulin, adipose tissue weight, oral glucose tolerance test (OGTT), total cholesterol, and triglyceride (TG) levels in mice were measured. Moreover, adiponectin, TG synthesis related gene expressions, and the inhibitory effect of aldose reductase (AR) were performed to evaluate its antidiabetic effects. After the 8-week treatment, blood glucose, insulin levels, and adipose tissue weight were significantly decreased. OGTT and HOMA-IR index showed improved glucose tolerance. It could also lower plasma TG, TC, and liver TG levels. Furthermore, Carassius auratus complex formula could inhibit the activity of AR and restore adiponectin expression in serum. Based on these findings, it is suggested that Carassius auratus complex formula possesses potent anti-diabetic effects on high fat diet combined STZ-induced diabetic mice.