Research Article

Antiplatelet Activity of Morus alba Leaves Extract, Mediated via Inhibiting Granule Secretion and Blocking the Phosphorylation of Extracellular-Signal-Regulated Kinase and Akt

Figure 5

Effects of Morus alba leaves extracts (MAE) on TXA2 formation from the collagen-stimulated platelets. Washed platelets (3 × 108/mL) were pre-incubated with MAE at the indicated concentrations and stirred in an aggregometer for 2 min prior to stimulation with 2.5 μg/mL collagen. The reaction was terminated at 5 min, and TXA2 formation was performed as described in Materials and Methods. Bar graphs show the mean ± SEM of triplicate independent experiments. ** and *** compared to the agonist control.
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