Antiplatelet Activity of Morus alba Leaves Extract, Mediated via Inhibiting Granule Secretion and Blocking the Phosphorylation of Extracellular-Signal-Regulated Kinase and Akt

Figure 8

Effect of Morus alba leaves extracts (MAE) on thrombus formation in rats. The procedures for the AV-shunt model are described in the Section 2. Thrombus weight in an arteriovenous shunt was measured at 2 h after administration of 3-day treatment with 0.25% carboxymethylcellulose solution (control), ethanol extract of Morus alba L. leaves (MAE) 100, 200 or 400 mg/kg/day, and positive control (rivaroxaban, RVX) 5 mg/kg/day. Data are shown as mean ± S.D. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 versus vehicle control.